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Comment
. 2020 Mar;35(3):400.
doi: 10.1002/mds.27990. Epub 2020 Feb 6.

Ferroptosis-Suppressor-Protein 1: A Potential Neuroprotective Target for Combating Ferroptosis

Leilei Chen  1 , Junxia Xie  1
Affiliations
Comment

Ferroptosis-Suppressor-Protein 1: A Potential Neuroprotective Target for Combating Ferroptosis

Leilei Chen et al. Mov Disord. 2020 Mar.
No abstract available

Keywords: FSP1; Parkinson's disease; ferroptosis.

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Comment on

  • FSP1 is a glutathione-independent ferroptosis suppressor.
    Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mourão A, Buday K, Sato M, Wanninger J, Vignane T, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad M. Doll S, et al. Nature. 2019 Nov;575(7784):693-698. doi: 10.1038/s41586-019-1707-0. Epub 2019 Oct 21. Nature. 2019. PMID: 31634899

References

    1. Moreau C, Duce JA, Rascol O, et al. Iron as a therapeutic target for Parkinson's disease. Mov Disord 2018;33(4):568-574.
    1. Do Van B, Gouel F, Jonneaux A, et al. Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC. Neurobiol Dis 2016;94:169-178.
    1. Yang WS, SriRamaratnam R, Welsch ME, et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014;156(1-2):317-331.
    1. Doll S, Freitas FP, Shah R, et al. FSP1 is a glutathione-independent ferroptosis suppressor. Nature 2019;575(7784):693-698.
    1. Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, et al. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 2019;575(7784):688-692.

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