Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1977 Mar;89(3):471-82.

Studies on the effects of C. coli endotoxin on canalicular bile formation in the isolated perfused rat liver

R Utili, C O Abernathy, H J Zimmerman
  • PMID: 320281

Studies on the effects of C. coli endotoxin on canalicular bile formation in the isolated perfused rat liver

R Utili et al. J Lab Clin Med. 1977 Mar.

Abstract

The impairment of biliary excretory function induced by E. coli endotoxin in the isolated perfused rat liver was studied by investigating its effects on canalicular bile formation. In experiments where no bile salt was infused, endotoxin administration resulted in significant decreases in bile salt-independent bile flow (BSIF) and sulfobromophthalein (BSP) excretion. It also caused dose-dependent decreases in the transport maximum of BSP but did not alter the ability of the liver to concentrate BSP in the bile. At 2 mg./100 ml. it decreased the hepatic removal rate but increased the hepatic storage of the dye. Measurement of 14 C-erythritol clearance and bile salt secretion also revealed that endotoxin significantly reduced the BSIF fraction of bile. The results indicated that the primary effects of endotoxin were on BSIF and BSP excretion.

PubMed Disclaimer