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Multicenter Study
. 2020 Feb;99(6):e19056.
doi: 10.1097/MD.0000000000019056.

Prevalence and predictors of peripherally inserted central venous catheter associated bloodstream infections in cancer patients: A multicentre cohort study

Jae Hwan Lee  1 , Min Uk Kim  2 , Eung Tae Kim  3   4 , Dong Jae Shim  5 , Il Jung Kim  6 , Jong Hyun Byeon  5 , Hyun Beom Kim  7   8
Affiliations
Multicenter Study

Prevalence and predictors of peripherally inserted central venous catheter associated bloodstream infections in cancer patients: A multicentre cohort study

Jae Hwan Lee et al. Medicine (Baltimore). 2020 Feb.

Abstract

Despite increasing use, the exact prevalence and predictors of peripherally inserted central catheter-associated bloodstream infection (PICC-CLABSI) in hospitalized patients with cancer are not elucidated.This retrospective cohort study included consecutive patients who underwent peripherally inserted central catheter (PICC) placement in 4 institutions (during 12 months in 3 hospitals and 10 months in 1 hospital). The prevalence of PICC-CLABSI was evaluated. The association between predictors and PICC-CLABSI were analyzed using Cox proportional hazards regression models and Kaplan-Meier survival analysis with log-rank tests.During the study period, 539 PICCs were inserted in 484 patients for a total of 10,841 catheter days. PICC-CLABSI occurred in 25 (5.2%) patients, with an infection rate of 2.31 per 1000 catheter days. PICC for chemotherapy (hazards ratio [HR] 11.421; 95% confidence interval (CI), 2.434-53.594; P = .019), double lumen catheter [HR 5.466; 95% CI, 1.257-23.773; P = .007], and PICC for antibiotic therapy [HR 2.854; 95% CI, 1.082-7.530; P = .019] were associated with PICC-CLABSI.PICC for chemotherapy or antibiotics, and number of catheter lumens are associated with increased risk of PICC-CLABSI in cancer patients. Careful assessment of these factors might help prevent PICC-CLABSI and improve cancer patients care.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Study flow diagram.
Figure 2
Figure 2
Kaplan-Meier analysis for predictors of PICC-CLABSI. 2-A; cumulative PICC-CLABSI free survival according to indwelling time of chemotherapy versus non-chemotherapy. 2-B; cumulative PICC-CLABSI free survival according to indwelling time of single lumen versus double lumen. 2-C; cumulative PICC-CLABSI free survival according to indwelling time of antibiotics versus non-antibiotics. PICC-CLABSI = peripherally inserted central catheter-associated bloodstream infection.
See this image and copyright information in PMC

References

    1. Ajenjo MC, Morley JC, Russo AJ, et al. Peripherally inserted central venous catheter-associated bloodstream infections in hospitalized adult patients. Infect Control Hosp Epidemiol 2011;32:125–30. - PubMed
    1. Cheong K, Perry D, Karapetis C, et al. High rate of complications associated with peripherally inserted central venous catheters in patients with solid tumours. Intern Med J 2004;34:234–8. - PubMed
    1. Bouzad C, Duron S, Bousquet A, et al. Peripherally inserted central catheter-related infections in a cohort of hospitalized adult patients. Cardiovasc Intervent Radiol 2016;39:385–93. - PubMed
    1. Walshe LJ, Malak SF, Eagan J, et al. Complication rates among cancer patients with peripherally inserted central catheters. J Clin Oncol 2002;20:3276–81. - PubMed
    1. Herc E, Patel P, Washer LL, et al. A model to predict central-line-associated bloodstream infection among patients with peripherally inserted central catheters: the MPC score. Infect Control Hosp Epidemiol 2017;38:1155–66. - PubMed

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