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Review
. 2020 Feb 3;21(3):1009.
doi: 10.3390/ijms21031009.

IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target

Tian-Yu Lin  1 , Yu-Hsiang Hsu  1   2
Affiliations
Review

IL-20 in Acute Kidney Injury: Role in Pathogenesis and Potential as a Therapeutic Target

Tian-Yu Lin et al. Int J Mol Sci. .

Abstract

Acute kidney injury (AKI) causes over 1 million deaths worldwide every year. AKI is now recognized as a major risk factor in the development and progression of chronic kidney disease (CKD). Diabetes is the main cause of CKD as well. Renal fibrosis and inflammation are hallmarks in kidney diseases. Various cytokines contribute to the progression of renal diseases; thus, many drugs that specifically block cytokine function are designed for disease amelioration. Numerous studies showed IL-20 functions as a pro-inflammatory mediator to regulate cytokine expression in several inflammation-mediated diseases. In this review, we will outline the effects of pro-inflammatory cytokines in the pathogenesis of AKI and CKD. We also discuss the role of IL-20 in kidney diseases and provide a potential therapeutic approach of IL-20 blockade for treating renal diseases.

Keywords: IL-20; acute kidney injury; chronic kidney disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The effect of IL-20 in renal cells. IL-20 acts on interstitial fibroblasts, renal epithelial cells, mesangial cells, and podocytes and contributes to the progression of kidney disease, including inflammatory response, renal fibrosis, and cell apoptosis. ↑ = increased; ↓ = decrease.
See this image and copyright information in PMC

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