Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 1;34(5-6):321-340.
doi: 10.1101/gad.334284.119. Epub 2020 Feb 6.

The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism

Magdolna Szántó  1 , Peter Bai  1   2   3
Affiliations
Review

The role of ADP-ribose metabolism in metabolic regulation, adipose tissue differentiation, and metabolism

Magdolna Szántó et al. Genes Dev. .

Abstract

Poly(ADP-ribose) polymerases (PARPs or ARTDs), originally described as DNA repair factors, have metabolic regulatory roles. PARP1, PARP2, PARP7, PARP10, and PARP14 regulate central and peripheral carbohydrate and lipid metabolism and often channel pathological disruptive metabolic signals. PARP1 and PARP2 are crucial for adipocyte differentiation, including the commitment toward white, brown, or beige adipose tissue lineages, as well as the regulation of lipid accumulation. Through regulating adipocyte function and organismal energy balance, PARPs play a role in obesity and the consequences of obesity. These findings can be translated into humans, as evidenced by studies on identical twins and SNPs affecting PARP activity.

Keywords: AFLD; ARTD; NAFLD; PARP; PARylation; adipocyte; adipogenesis; atherosclerosis; beige adipocytes; brown adipocytes; differentiation; high fat diet; insulin resistance; lipolysis; mitochondria; obesity; stem cell; white adipocytes.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
The general scheme of adipose tissue lineage differentiation. Abbreviations are defined in the text.
Figure 2.
Figure 2.
The involvement of PARP enzymes in the transcriptional control of white adipogenesis. Abbreviations are defined in the text.
See this image and copyright information in PMC

References

    1. Abdul-Rahman O, Kristóf E, Doan-Xuan QM, Vida A, Nagy L, Horváth A, Simon J, Maros T, Szentkirályi I, Palotás L, et al. 2016. AMP-activated kinase (AMPK) activation by AICAR in human white adipocytes derived from pericardial white adipose tissue stem cells induces a partial beige-like phenotype. PLoS One 11: e0157644 10.1371/journal.pone.0157644 - DOI - PMC - PubMed
    1. Abplanalp J, Hopp AK, Hottiger MO. 2018. Mono-ADP-ribosylhydrolase assays. Methods Mol Biol 1813: 205–213. 10.1007/978-1-4939-8588-3_13 - DOI - PubMed
    1. Ambrose HE, Willimott S, Beswick RW, Dantzer F, de Murcia JM, Yelamos J, Wagner SD. 2009. Poly(ADP-ribose) polymerase-1 (Parp-1)-deficient mice demonstrate abnormal antibody responses. Immunology 127: 178–186. 10.1111/j.1365-2567.2008.02921.x - DOI - PMC - PubMed
    1. Amé JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Höger T, Menissier-de Murcia J, de Murcia G. 1999. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 274: 17860–17868. 10.1074/jbc.274.25.17860 - DOI - PubMed
    1. Amé JC, Spenlehauer C, de Murcia G. 2004. The PARP superfamily. Bioessays 26: 882–893. 10.1002/bies.20085 - DOI - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources