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Review
. 2020 Apr;61(4):470-479.
doi: 10.1194/jlr.R119000547. Epub 2020 Feb 6.

Alcohol effects on hepatic lipid metabolism

Sookyoung Jeon  1 , Rotonya Carr  2
Affiliations
Review

Alcohol effects on hepatic lipid metabolism

Sookyoung Jeon et al. J Lipid Res. 2020 Apr.

Abstract

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease with significant morbidity and mortality worldwide. ALD begins with simple hepatic steatosis and progresses to alcoholic steatohepatitis, fibrosis, and cirrhosis. The severity of hepatic steatosis is highly associated with the development of later stages of ALD. This review explores the disturbances of alcohol-induced hepatic lipid metabolism through altered hepatic lipid uptake, de novo lipid synthesis, fatty acid oxidation, hepatic lipid export, and lipid droplet formation and catabolism. In addition, we review emerging data on the contributions of genetics and bioactive lipid metabolism in alcohol-induced hepatic lipid accumulation.

Keywords: alcoholic liver disease; fatty acid oxidation; fatty acid uptake; lipid droplets; lipogenesis; steatosis.

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Conflict of interest statement

R.C. receives research salary support from Intercept and has received compensation as an invited speaker at Boehringer. S.J. declares no conflicts of interest with the contents of this article.

Figures

Fig. 1.
Fig. 1.
Mechanisms of alcohol-induced hepatic lipid accumulation.
See this image and copyright information in PMC

References

    1. Asrani S. K., Devarbhavi H., Eaton J., and Kamath P. S.. 2019. Burden of liver diseases in the world. J. Hepatol. 70: 151–171. - PubMed
    1. Edmondson H. A., Peters R. L., Frankel H. H., and Borowsky S.. 1967. The early stage of liver injury in the alcoholic. Medicine (Baltimore). 46: 119–129. - PubMed
    1. Powell E. E., Jonsson J. R., and Clouston A. D.. 2005. Steatosis: co-factor in other liver diseases. Hepatology. 42: 5–13. - PubMed
    1. Lazo M., and Mitchell M. C.. 2016. Epidemiology and risk factors for alcoholic liver disease. In Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to Bedside. N. Chalasani and G. Szabo, editors. Springer International Publishing, Cham, Switzerland. 1–20.
    1. Zakhari S. 2006. Overview: how is alcohol metabolized by the body? Alcohol Res. Health. 29: 245–254. - PMC - PubMed

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