Knocking out barriers to engineered cell activity

Jennifer R Hamilton^{1

2}, Jennifer A Doudna^{3

2

4

5

6

7

8}

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
² Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
³ Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. doudna@berkeley.edu.
⁴ Department of Chemistry, University of California, Berkeley, CA 94720, USA.
⁵ California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720, USA.
⁶ Innovative Genomics Institute, University of California, Berkeley, CA 94720, USA.
⁷ MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
⁸ Gladstone Institutes, University of California, San Francisco, CA 94114, USA.

Free article

Comment

Jennifer R Hamilton et al. Science. 2020.

Free article

. 2020 Feb 28;367(6481):976-977.

doi: 10.1126/science.aba9844. Epub 2020 Feb 6.

Jennifer R Hamilton^{1

2}, Jennifer A Doudna^{3

2

4

5

6

7

8}

¹ Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
² Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.
³ Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. doudna@berkeley.edu.
⁴ Department of Chemistry, University of California, Berkeley, CA 94720, USA.
⁵ California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720, USA.
⁶ Innovative Genomics Institute, University of California, Berkeley, CA 94720, USA.
⁷ MBIB Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
⁸ Gladstone Institutes, University of California, San Francisco, CA 94114, USA.

No abstract available

Comment on

CRISPR-engineered T cells in patients with refractory cancer.
Stadtmauer EA, Fraietta JA, Davis MM, Cohen AD, Weber KL, Lancaster E, Mangan PA, Kulikovskaya I, Gupta M, Chen F, Tian L, Gonzalez VE, Xu J, Jung IY, Melenhorst JJ, Plesa G, Shea J, Matlawski T, Cervini A, Gaymon AL, Desjardins S, Lamontagne A, Salas-Mckee J, Fesnak A, Siegel DL, Levine BL, Jadlowsky JK, Young RM, Chew A, Hwang WT, Hexner EO, Carreno BM, Nobles CL, Bushman FD, Parker KR, Qi Y, Satpathy AT, Chang HY, Zhao Y, Lacey SF, June CH. Stadtmauer EA, et al. Science. 2020 Feb 28;367(6481):eaba7365. doi: 10.1126/science.aba7365. Epub 2020 Feb 6. Science. 2020. PMID: 32029687 Free PMC article. Clinical Trial.