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. 2020 Feb 6;11(1):804.
doi: 10.1038/s41467-019-13988-4.

Photons as a 21st century reagent

Holly E Bonfield  1   2 , Thomas Knauber  3 , François Lévesque  4 , Eric G Moschetta  5 , Flavien Susanne  1 , Lee J Edwards  6
Affiliations

Photons as a 21st century reagent

Holly E Bonfield et al. Nat Commun. .

Abstract

A pharmaceutical industry viewpoint on how the fundamental laws of photochemistry are used to identify the parameters required to implement photochemistry from lab to scale. Parameters such as photon stoichiometry and light intensity are highlighted within to inform future publications.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Comparison of a commonly used light source.
a Spectral output overlays of a 34 W blue LED (A) at intensity setting 10 and color settings 1–6. b Spectral output overlays of a 34 W blue LED (B) at intensity setting 10 and color settings 1–6. LED A and B are the same maker and model from different batches; both are emitting from violet to red light. Figure adapted from (10.1002/cptc.201900203). Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.
Fig. 2
Fig. 2. Comparison of the spectral outputs and relative light intensities of commonly used light sources.
a 12 W medium pressure mercury lamp; b two CFLs (overlaid); c a 450 nm LED flow reactor, and a blue LED screening platform at 30 mA (overlaid). Figure adapted from (10.1002/cptc.201900203). Copyright Wiley-VCH Verlag GmbH & Co. KGaA. Reproduced with permission.
See this image and copyright information in PMC

References

    1. Hoffmann N. Photochemical reactions of aromatic compounds and the concept of the photon as a traceless reagent. Photochem. Photobiol. Sci. 2012;11:1613–1641. doi: 10.1039/c2pp25074h. - DOI - PubMed
    1. Turro, N. J., Ramamurthy, V. & Scaiano, J. C. Modern Molecular Photochemistry For Organic Molecules (University Science Books, CA, 2017).
    1. Twilton, J. et al. The merger of transition metal and photocatalysis. Nat. Rev. Chem.1, 0052 10.1038/s41570-017-0052 (2017).
    1. Blakemore DC, et al. Organic synthesis provides opportunities to transform drug discovery. Nat. Chem. 2018;10:383–394. doi: 10.1038/s41557-018-0021-z. - DOI - PubMed
    1. Mennen SM, et al. The evolution of high-throughput experimentation in pharmaceutical development and perspectives on the future. Org. Process Res. Dev. 2019;23:1213–1242. doi: 10.1021/acs.oprd.9b00140. - DOI