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Review
. 2020 Jan 22:13:1179551419892985.
doi: 10.1177/1179551419892985. eCollection 2020.

PYY, a Therapeutic Option for Type 2 Diabetes?

Claudia Guida  1 , Reshma Ramracheya  1
Affiliations
Review

PYY, a Therapeutic Option for Type 2 Diabetes?

Claudia Guida et al. Clin Med Insights Endocrinol Diabetes. .

Abstract

Metabolic surgery leads to rapid and effective diabetes reversal in humans, by weight-independent mechanisms. The crucial improvement in pancreatic islet function observed after surgery is induced by alteration in several factors, including gut hormones. In addition to glucagon-like peptide 1 (GLP-1), increasing lines of evidence show that peptide tyrosine tyrosine (PYY) plays a key role in the metabolic benefits associated with the surgery, ranging from appetite regulation to amelioration of islet secretory properties and survival. Here, we summarize the current knowledge and the latest advancements in the field, which pitch a strong case for the development of novel PYY-based therapy for the treatment of diabetes.

Keywords: PYY; bariatric surgery; diabetes; pancreatic islets.

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Conflict of interest statement

Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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