Early neuromuscular blockade in acute respiratory distress syndrome: to personalize or paralyze?

Ken Kuljit S Parhar¹, Kevin Solverson¹, Vasileios Zochios^{2

3}

Affiliations

¹ Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Foothills Medical Center, Calgary, Canada.
² University Hospitals of Leicester, National Health Services Trust, Departments of Anesthesia and Intensive Care, Glenfield Hospital, Leicester, UK.
³ University of Birmingham, College of Medical and Dental Sciences, Institute of Inflammation and Ageing, Birmingham, UK.

Editorial

Ken Kuljit S Parhar et al. J Thorac Dis. 2019 Dec.

. 2019 Dec;11(12):5701-5705.

doi: 10.21037/jtd.2019.12.101.

Ken Kuljit S Parhar¹, Kevin Solverson¹, Vasileios Zochios^{2

3}

¹ Department of Critical Care Medicine, University of Calgary and Alberta Health Services, Foothills Medical Center, Calgary, Canada.
² University Hospitals of Leicester, National Health Services Trust, Departments of Anesthesia and Intensive Care, Glenfield Hospital, Leicester, UK.
³ University of Birmingham, College of Medical and Dental Sciences, Institute of Inflammation and Ageing, Birmingham, UK.

No abstract available

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
National Heart, Lung, and Blood Institute PETAL Clinical Trials Network; Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, et al. N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112383 Free PMC article. Clinical Trial.

1. Ranieri VM, Rubenfeld GD, Thompson BT, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33. - PubMed
1. Bellani G, Laffey JG, Pham T, et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA 2016;315:788-800. 10.1001/jama.2016.0291 - DOI - PubMed
1. Parhar KKS, Zjadewicz K, Soo A, et al. Epidemiology, Mechanical Power, and 3-Year Outcomes in Acute Respiratory Distress Syndrome Patients Using Standardized Screening. An Observational Cohort Study. Ann Am Thorac Soc 2019;16:1263-72. 10.1513/AnnalsATS.201812-910OC - DOI - PMC - PubMed
1. Herridge MS, Tansey CM, Matte A, et al. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med 2011;364:1293-304. 10.1056/NEJMoa1011802 - DOI - PubMed
1. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med 2014;370:980. - PubMed