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Review
. 2020:1225:71-87.
doi: 10.1007/978-3-030-35727-6_5.

Multimodal Molecular Imaging of the Tumour Microenvironment

Claudia Foray  1   2 , Cristina Barca  1   2 , Philipp Backhaus  1   3 , Sonja Schelhaas  1 , Alexandra Winkeler  4 , Thomas Viel  5 , Michael Schäfers  1   3 , Oliver Grauer  6 , Andreas H Jacobs  1   2   7 , Bastian Zinnhardt  8   9   10
Affiliations
Review

Multimodal Molecular Imaging of the Tumour Microenvironment

Claudia Foray et al. Adv Exp Med Biol. 2020.

Erratum in

Abstract

The tumour microenvironment (TME) surrounding tumour cells is a highly dynamic and heterogeneous composition of immune cells, fibroblasts, precursor cells, endothelial cells, signalling molecules and extracellular matrix (ECM) components. Due to the heterogeneity and the constant crosstalk between the TME and the tumour cells, the components of the TME are important prognostic parameters in cancer and determine the response to novel immunotherapies. To improve the characterization of the TME, novel non-invasive imaging paradigms targeting the complexity of the TME are urgently needed.The characterization of the TME by molecular imaging will (1) support early diagnosis and disease follow-up, (2) guide (stereotactic) biopsy sampling, (3) highlight the dynamic changes during disease pathogenesis in a non-invasive manner, (4) help monitor existing therapies, (5) support the development of novel TME-targeting therapies and (6) aid stratification of patients, according to the cellular composition of their tumours in correlation to their therapy response.This chapter will summarize the most recent developments and applications of molecular imaging paradigms beyond FDG for the characterization of the dynamic molecular and cellular changes in the TME.

Keywords: Cancer; Cancer-Associated Fibroblasts; GAMM; Glioma; Immunotherapy; MRI; Molecular imaging; Myeloid derived suppressor cells; PET; TAM; TME; TSPO; Tumour infiltrating lymphocytes; Tumour microenvironment; Vasculature.

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References

    1. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646–674. https://doi.org/10.1016/j.cell.2011.02.013 - DOI - PubMed - PMC
    1. Inda M-D-M, Bonavia R, Seoane J (2014) Glioblastoma multiforme: a look inside its heterogeneous nature. Cancers (Basel) 6:226–239
    1. Villa A et al (2018) Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state. Theranostics 8:5400–5418 - PubMed - PMC
    1. Derlin T, Grünwald V, Steinbach J, Wester HJ, Ross TL (2018) Molecular imaging in oncology using positron emission tomography. Dtsch Arztebl Int 115(11):175–181. https://doi.org/10.3238/arztebl.2018.0175
    1. Di Chiro G (1987) Positron emission tomography using [18F] fluorodeoxyglucose in brain tumors a powerful diagnostic and prognostic tool. Investig Radiol 22:360–371

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