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Review
. 2020:1225:127-135.
doi: 10.1007/978-3-030-35727-6_9.

Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses

Christian Münz  1
Affiliations
Free article
Review

Tumor Microenvironment Conditioning by Abortive Lytic Replication of Oncogenic γ-Herpesviruses

Christian Münz. Adv Exp Med Biol. 2020.
Free article

Abstract

Epstein Barr virus (EBV) and Kaposi sarcoma-associated herpesvirus (KSHV) constitute the human γ-herpesviruses and two of the seven human tumor viruses. In addition to their viral oncogenes that primarily belong to the latent infection programs of these viruses, they encode proteins that condition the microenvironment. Many of these are early lytic gene products and are only expressed in a subset of infected cells of the tumor mass. In this chapter I will describe their function and the evidence that targeting them in addition to the latent oncogenes could be beneficial for the treatment of EBV- and KSHV-associated malignancies.

Keywords: Angiogenesis; Burkitt’s lymphoma; CCL5; Epstein Barr virus; Hodgkin’s lymphoma; Kaposi sarcoma; Kaposi sarcoma-associated herpesvirus; Lytic replication; Multicentric Castleman’s disease; Nasopharyngeal carcinoma; Primary effusion lymphoma; Viral IL-10; Viral IL-6; Viral MIP; Viral miRNA.

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