Adipose Tumor Microenvironment

Abstract

The term "adipose tissue" represents a multicellular and multifunctional organ involved in lipid storage, in hormone and temperature regulation, and in the protection of bones and vital organs from impact-based damage. Emerging evidence now suggests a more malignant role of adipose tissue in promoting cancer onset and progression via the release of secreted factors such as interleukin-6 (IL6) and extracellular vesicles (EVs). These adipose-source factors subsequently affect various aspects of tumorigenesis and/or cancer progression by either directly enhancing the tumor cell oncogenic phenotype or indirectly by the stimulating adjacent normal cells to adopt a more pro-cancer phenotype. Due to the recent growing interest in the role of IL6 and EVs released by adipose tissue in cancer promotion and progression, we are focusing on the protumorigenic impact of fat tissue via IL6 and EV secretion.

Keywords: Adipocytes; Adipokines; Adipose tumor; Cancer; Cell-to-cell communication; Extracellular vesicles; Fibroblasts; Glycoprotein 130; Inflammation; Interleukin-6; Liposarcoma; Macrophages; Preadipocytes; Signal transduction; Tumor microenvironment.