Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct;235(10):6942-6953.
doi: 10.1002/jcp.29590. Epub 2020 Feb 6.

Clinicopathological and prognostic significance of PD-1/PD-L1 axis expression in patients with tongue squamous cell carcinoma

Weilun Huang  1 , Xiao Zhou  1 , Qianjin Liao  2 , Yanyan Tang  2 , Liang Zuo  1 , Honghan Wang  1 , Xing Chen  1 , Xiaoyan Chen  3 , Junjun Li  3 , Songlin Zhu  4 , Jun Deng  4 , Yan Liu  1 , Kunjie Zhu  1 , Jianjun Yu  1 , Wei Xiong  5
Affiliations

Clinicopathological and prognostic significance of PD-1/PD-L1 axis expression in patients with tongue squamous cell carcinoma

Weilun Huang et al. J Cell Physiol. 2020 Oct.

Abstract

Tongue squamous cell carcinoma (TSCC) is more aggressive than other head and neck tumors, and the prognosis for patients with advanced TSCC is poor. At present, comprehensive treatment based on surgery as the main method is not effective for patients with advanced TSCC. The application of PD-1/PD-L1 immunocheckpoint inhibitor alone in patients with TSCC has not been reported. To explore the role of PD-1/PD-L1, we investigated the expression of PD-1 and PD-L1 in TSCC and analyzed the relationship between the expression of PD-1 and PD-L1 and the related clinicopathological parameters and survival prognosis. The expression of PD-1 was significantly associated with palindromia (p = .015) and maximum diameter (p = .043). The expression of PD-L1 in tumor cells was significantly associated with N stage (P = .024), chemotherapy (p = .032), and clinical stage (p = .019). The expression of PD-L1 in infiltrating lymphocytes was significantly associated with palindromia (p = .030). Univariate and multivariate Cox analyses for prognoses of patients showed significant prognostic factors of overall survival and relapse-free survival. The high expression of PD-L1 on infiltrating lymphocytes for OS and RFS was an independent protective factor for patients with TSCC. The high expression of PD-1 on infiltrating lymphocytes and clinical stage for OS and RFS were independent risk factors for patients with TSCC. The data provide a reference for clinical treatment of TSCC with immunotherapy.

Keywords: PD-1; PD-L1; independent risk factors; tongue squamous cell carcinoma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Adel, M., Liao, C. T., Lee, L. Y., Hsueh, C., Lin, C. Y., Fan, K. H., … Yen, T. C. (2016). Incidence and outcomes of patients with oral cavity squamous cell carcinoma and fourth primary tumors: A long-term follow-up study in a betel quid chewing endemic area. Medicine, 95(12), e2950.
    1. Azuma, T., Yao, S., Zhu, G., Flies, A. S., Flies, S. J., & Chen, L. (2008). B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood, 111(7), 3635-3643.
    1. Bello, I. O., Soini, Y., & Salo, T. (2010). Prognostic evaluation of oral tongue cancer: Means, markers and perspectives (I). Oral Oncology, 46(9), 630-635.
    1. Chow, L., Haddad, R., Gupta, S., Mahipal, A., Mehra, R., Tahara, M., … Seiwert, T. Y. (2016). Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results from the phase Ib KEYNOTE-012 expansion cohort. Journal of Clinical Oncology, 34(32), 3838-3845.
    1. Cui, S., Su, X., Dong, L., Qian, J., Ye, L., Zhang, T., … Jiang, L. (2017). Programmed cell death ligand 1 protein levels predicted survival of non-small cell lung cancer. Journal of Cancer, 8(19), 4075-4082.

Publication types

LinkOut - more resources