Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Jennifer Zeitlin¹, Rolf F Maier², Marina Cuttini³, Ulrika Aden⁴, Klaus Boerch⁵, Janusz Gadzinowski⁶, Pierre-Henri Jarreau⁷, Jo Lebeer⁸, Mikael Norman^{9

10}, Pernille Pedersen¹¹, Stavros Petrou^{12

13}, Johanna M Pfeil¹⁴, Liis Toome¹⁵, Arno van Heijst¹⁶, Patrick Van Reempts¹⁷, Heili Varendi¹⁸, Henrique Barros¹⁹, Elizabeth S Draper²⁰; EPICE and SHIPS Research Group

Collaborators, Affiliations

Collaborators

EPICE and SHIPS Research Group:
J Lebeer, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus, I Sarrechia, K Boerch, L Huusom, P Pedersen, T Weber, L Toome, H Varendi, M Männamaa, P Y Ancel, A Burguet, P H Jarreau, V Pierrat, P Truffert, R F Maier, M Zemlin, B Misselwitz, S Schmidt, L Wohlers, M Cuttini, D Di Lallo, G Ancora, D Baronciani, V Carnielli, I Croci, G Faldella, F Ferrari, F Franco, G Gargano, A van Heijst, C Koopman-Esseboom, J Gadzinowski, J Mazela, A Montgomery, T Pikuła, H Barros, R Costa, L Mendes Graça, M do Céu Machado, C Rodrigues, T Rodrigues, U Aden, A K Edstedt Bonamy, M Norman, E S Draper, E M Boyle, A Fenton, S J Johnson, B N Manktelow, D W A Milligan, S Mader, N Thiele, J M Walz, S Petrou, J Zeitlin, M Bonet, C Bonnet, R El Raffei, A Piedvache, A V Seppanen

Affiliations

¹ INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.
² Children's Hospital, University Hospital, Philipps University Marburg, Marburg, Germany.
³ Clinical Care and Management Innovation Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁴ Department of Womeńs and Childreńs Health, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Paediatrics, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark.
⁶ Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
⁷ Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaire Paris Centre Site Cochin, DHU Risks in pregnancy, Service de Médecine et Réanimation néonatales de Port-Royal, Paris, France.
⁸ Department of Primary & Interdisciplinary Care, Disability Studies, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
⁹ Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.
¹⁰ Department of Neonatal Medicine, Karolinska University Hospital, Stockholm, Sweden.
¹¹ Department of Neonatology, Hvidovre Hospital, Hvidovre, Denmark.
¹² The University of Warwick, Warwick Medical School (WMS), Coventry, UK.
¹³ University of Oxford, Nuffield Department of Primary Care Health Sciences, Oxford, UK.
¹⁴ European Foundation for the Care of Newborn Infants (EFCNI), Munich, Germany.
¹⁵ Tallinn Children's Hospital, Tallinn, Estonia and University of Tartu, Tartu, Estonia.
¹⁶ Department of Neonatology, Radboud University Medical Center, Nijmegen, the Netherlands.
¹⁷ Department of Neonatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium and Study Centre for Perinatal Epidemiology, Brussels, Belgium.
¹⁸ University of Tartu, Tartu University Hospital, Tartu, Estonia.
¹⁹ EPIUnit--Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
²⁰ Department of Health Sciences, University of Leicester, Leicester, UK.

PMID: 32031620
PMCID: PMC7266542
DOI: 10.1093/ije/dyz270

Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Jennifer Zeitlin et al. Int J Epidemiol. 2020.

. 2020 Apr 1;49(2):372-386.

doi: 10.1093/ije/dyz270.

Authors

Collaborators

EPICE and SHIPS Research Group:
J Lebeer, P Van Reempts, E Bruneel, E Cloet, A Oostra, E Ortibus, I Sarrechia, K Boerch, L Huusom, P Pedersen, T Weber, L Toome, H Varendi, M Männamaa, P Y Ancel, A Burguet, P H Jarreau, V Pierrat, P Truffert, R F Maier, M Zemlin, B Misselwitz, S Schmidt, L Wohlers, M Cuttini, D Di Lallo, G Ancora, D Baronciani, V Carnielli, I Croci, G Faldella, F Ferrari, F Franco, G Gargano, A van Heijst, C Koopman-Esseboom, J Gadzinowski, J Mazela, A Montgomery, T Pikuła, H Barros, R Costa, L Mendes Graça, M do Céu Machado, C Rodrigues, T Rodrigues, U Aden, A K Edstedt Bonamy, M Norman, E S Draper, E M Boyle, A Fenton, S J Johnson, B N Manktelow, D W A Milligan, S Mader, N Thiele, J M Walz, S Petrou, J Zeitlin, M Bonet, C Bonnet, R El Raffei, A Piedvache, A V Seppanen

Affiliations

¹ INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.
² Children's Hospital, University Hospital, Philipps University Marburg, Marburg, Germany.
³ Clinical Care and Management Innovation Research Area, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
⁴ Department of Womeńs and Childreńs Health, Karolinska Institutet, Stockholm, Sweden.
⁵ Department of Paediatrics, Hvidovre Hospital, Copenhagen University Hospital, Hvidovre, Denmark.
⁶ Department of Neonatology, Poznan University of Medical Sciences, Poznan, Poland.
⁷ Université Paris Descartes and Assistance Publique Hôpitaux de Paris, Hôpitaux Universitaire Paris Centre Site Cochin, DHU Risks in pregnancy, Service de Médecine et Réanimation néonatales de Port-Royal, Paris, France.
⁸ Department of Primary & Interdisciplinary Care, Disability Studies, Faculty of Medicine, University of Antwerp, Antwerp, Belgium.
⁹ Department of Clinical Science, Intervention and Technology, Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.
¹⁰ Department of Neonatal Medicine, Karolinska University Hospital, Stockholm, Sweden.
¹¹ Department of Neonatology, Hvidovre Hospital, Hvidovre, Denmark.
¹² The University of Warwick, Warwick Medical School (WMS), Coventry, UK.
¹³ University of Oxford, Nuffield Department of Primary Care Health Sciences, Oxford, UK.
¹⁴ European Foundation for the Care of Newborn Infants (EFCNI), Munich, Germany.
¹⁵ Tallinn Children's Hospital, Tallinn, Estonia and University of Tartu, Tartu, Estonia.
¹⁶ Department of Neonatology, Radboud University Medical Center, Nijmegen, the Netherlands.
¹⁷ Department of Neonatology, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium and Study Centre for Perinatal Epidemiology, Brussels, Belgium.
¹⁸ University of Tartu, Tartu University Hospital, Tartu, Estonia.
¹⁹ EPIUnit--Instituto de Saúde Pública da Universidade do Porto, Porto, Portugal.
²⁰ Department of Health Sciences, University of Leicester, Leicester, UK.

PMID: 32031620
PMCID: PMC7266542
DOI: 10.1093/ije/dyz270

No abstract available

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Figures

**Figure 1.**
Regions included in the EPICE/SHIPS cohort: Flanders in Belgium; the Eastern Region of Denmark; Estonia (entire country); Burgundy, Ile-de-France and the Northern regions in France; Hesse and Saarland in Germany; Emilia- Romagna, Lazio and Marche regions in Italy; the Central and Eastern regions of The Netherlands; Wielkopolska in Poland; the Lisbon and Northern regions of Portugal; and the East Midlands, Northern and Yorkshire and Humber regions in the UK; and the Stockholm region in Sweden.

**Figure 2.**
Inclusions in the EPICE very preterm birth cohort and maternity and neonatal unit study. Large units are neonatal units with ≥10 very preterm admissions per year and associated maternity units.

**Figure 3**
Follow-up of the EPICE cohort.

**Figure 4**
Follow-up rates at 2 and 5 years by country.

See this image and copyright information in PMC

References

1. Euro-Peristat Project. European Perinatal Health Report. Core indicators of the health and care of pregnant women and babies in Europe in 2015. 2018. http://www.europeristat.com/index.php/reports/european-perinatal-health-....
1. Cheong JLY, Anderson PJ, Burnett AC. et al. Changing neurodevelopment at 8 years in children born extremely preterm since the 1990s. Pediatrics 2017;139:e20164086. - PubMed
1. Twilhaar ES, Wade RM, de Kieviet JF, van Goudoever JB, van Elburg RM, Oosterlaan J.. Cognitive outcomes of children born extremely or very preterm since the 1990s and associated risk factors: a meta-analysis and meta-regression. JAMA Pediatr 2018;172:361–67. - PMC - PubMed
1. Draper ES, Zeitlin J, Fenton AC. et al. Investigating the variations in survival rates for very preterm infants in 10 European regions: the MOSAIC birth cohort. Arch Dis Child Fetal Neonatal Ed 2008;94:F158–163. - PubMed
1. Zeitlin J, Draper ES, Kollee L. et al. Differences in rates and short-term outcome of live births before 32 weeks of gestation in Europe in 2003: results from the MOSAIC cohort. Pediatrics 2008;121:e936–944. - PubMed

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Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Collaborators

Affiliations

Cohort Profile: Effective Perinatal Intensive Care in Europe (EPICE) very preterm birth cohort

Authors

Collaborators

Affiliations

Figures

References

MeSH terms

LinkOut - more resources

Full Text Sources

Medical