Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens
- PMID: 32032520
- DOI: 10.1016/j.stem.2019.12.010
Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens
Abstract
Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities and pathophysiologic contributions.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.Cell Stem Cell. 2019 Dec 5;25(6):797-813.e9. doi: 10.1016/j.stem.2019.11.004. Cell Stem Cell. 2019. PMID: 31809738 Free PMC article.
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Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors.Cell Stem Cell. 2020 Feb 6;26(2):205-220.e8. doi: 10.1016/j.stem.2019.12.008. Epub 2020 Jan 23. Cell Stem Cell. 2020. PMID: 31978365
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