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Comment
. 2020 Feb 6;26(2):129-130.
doi: 10.1016/j.stem.2019.12.010.

Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens

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Keeping Fibrotic Responses in Contractile Tissues at Bay: The Plot t(Hic1)ens

Johnny Kim et al. Cell Stem Cell. .
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Abstract

Two recent papers in Cell Stem Cell by Soliman et al. (2020) and Scott et al. (2019) explore the contributions of mesenchymal progenitor cells to fibrosis in heart and skeletal muscle. They find tissue-dependent roles for a subpopulation of mesenchymal progenitors expressing Hic1 with varied differentiation capacities and pathophysiologic contributions.

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