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Review
. 2020 Feb 5;8(1):16.
doi: 10.3390/pharmacy8010016.

Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population

Kate O'Hara  1 , Jennifer H Martin  1 , Jennifer J Schneider  1
Affiliations
Review

Barriers and Challenges in Performing Pharmacokinetic Studies to Inform Dosing in the Neonatal Population

Kate O'Hara et al. Pharmacy (Basel). .

Abstract

A number of barriers and challenges must be overcome in order to conduct the pharmacokinetic studies that are urgently needed to inform the selection and dosing of medication in neonates. However, overcoming these barriers can be difficult. This review outlines the common barriers researchers are confronted with, including issues with ethics approval and consent, study design for pharmacokinetic studies and the ability to measure the drug concentrations in the blood samples obtained. Strategies to overcome these challenges are also proposed.

Keywords: biomedical; drug; ethics; modeling; neonate; pharmacokinetics; translational research.

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Conflict of interest statement

The authors declare no conflict of interest.

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