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Review
. 2020 Mar;49(1):141-149.
doi: 10.1016/j.gtc.2019.10.002. Epub 2019 Dec 24.

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Julia Wattacheril  1
Affiliations
Review

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

Julia Wattacheril. Gastroenterol Clin North Am. 2020 Mar.

Abstract

Nonalcoholic fatty liver disease (NAFLD) represents a global public health burden. NAFLD, while strongly associated with the metabolic syndrome, can occur independently from existing metabolic diseases. In addition to liver-related disease burden and mortality, significant extrahepatic disease outcomes coexist with NAFLD, including cardiovascular diseases, chronic kidney disease, and type 2 diabetes. Management of these comorbidities contributes to the overall public health burden of NAFLD. These extrahepatic manifestations require healthcare interventions that are vigilant in monitoring for progression of liver disease while simultaneously managing overall morbidity and mortality from other organ systems.

Keywords: CKD; Cardiovascular; Diabetes; Extrahepatic; Fatty liver; Heart failure.

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