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Review
. 2020 Mar;49(1):45-62.
doi: 10.1016/j.gtc.2019.09.002. Epub 2019 Dec 24.

How to Identify the Patient with Nonalcoholic Steatohepatitis Who Will Progress to Cirrhosis

Zachary H Henry  1 , Curtis K Argo  2
Affiliations
Review

How to Identify the Patient with Nonalcoholic Steatohepatitis Who Will Progress to Cirrhosis

Zachary H Henry et al. Gastroenterol Clin North Am. 2020 Mar.

Abstract

Non-alcoholic fatty liver disease (NAFLD) figures prominently into the clinical hepatology landscape. NAFLD represents a disease spectrum comprising simple steatosis, steatosis with elevated liver enzymes, and non-alcoholic steatohepatitis (NASH), the entity with clear potential for fibrosis progression. Risk factors associated with fibrosis progression in NASH include histologic findings of lobular inflammation and any fibrosis as well as clinical comorbidities that include type 2 diabetes, obesity, and metabolic syndrome. Liver biopsy remains the gold standard in evaluating NASH; however, noninvasive methods are accumulating evidence for a growing role in identifying patients at increased risk to develop NASH, fibrosis, and potentially cirrhosis.

Keywords: Cirrhosis; Fatty liver; Fibrosis; Obesity; Steatohepatitis.

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Conflict of interest statement

Conflict of Interest Statement The authors do not have any commercial associations that might pose a conflict of interest in connection with the submitted article.

MeSH terms