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. 2020 Apr;41(4):225-227.
doi: 10.1016/j.tips.2020.01.007. Epub 2020 Feb 4.

DELs Inside Cells

Animesh Roy  1 , Thomas Kodadek  2
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DELs Inside Cells

Animesh Roy et al. Trends Pharmacol Sci. 2020 Apr.

Abstract

DNA-encoded libraries (DELs) comprise large numbers of small molecules, each of which is conjugated to an encoding DNA. Krusemark and colleagues recently described a method to introduce DELs into living cells and recover conjugates that bind to an intracellular target. This proof-of-principle study suggests that it may be feasible to screen DELs against protein targets in their native environment.

Keywords: DNA-encoded library; cell-penetrating peptide; cellular assay; high-throughput screening; probe discovery.

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