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Randomized Controlled Trial
. 2020 Mar-Apr;63(2):125-133.
doi: 10.1016/j.pcad.2020.02.003. Epub 2020 Feb 5.

Protocol paper: Stepped wedge cluster randomized trial translating the ABCS into optimizing cardiovascular care for people living with HIV

Stephen K Williams  1 , Brent A Johnson  2 , Jonathan N Tobin  3 , Amneris Esther Luque  4 , Mechelle Sanders  5 , Jennifer K Carroll  6 , Andrea Cassells  7 , Tameir Holder  7 , Kevin Fiscella  8
Affiliations
Randomized Controlled Trial

Protocol paper: Stepped wedge cluster randomized trial translating the ABCS into optimizing cardiovascular care for people living with HIV

Stephen K Williams et al. Prog Cardiovasc Dis. 2020 Mar-Apr.

Abstract

People living with HIV (PWH) are at higher risk for cardiovascular disease (CVD) and stroke in comparison to their non-infected counterparts. The ABCS (aspirin-blood pressure control-cholesterol control-smoking cessation) reduce atherosclerotic (ASCVD) risk in the general population, but little is known regarding strategies for promoting the ABCS among PWH. Guided by the Consolidated Framework for Implementation Research (CFIR), we designed multilevel implementation strategies that target PWH and their clinicians to promote appropriate use of the ABCS based on a 10-year estimated ASCVD risk. Implementation strategies include patient coaching, automated texting, peer phone support, academic detailing and audit and feedback for the patient's clinician. We are evaluating implementation through a stepped wedge cluster randomized trial based on the Reach-Effectiveness-Adoption-Maintenance/Qualitative-Evaluation-for-Systematic-Translation (RE-AIM/QuEST) mixed methods framework that integrates quantitative and qualitative assessments. The primary outcome is change in ASCVD risk. Findings will have important implications regarding strategies for reducing ASCVD risk among PWH.

Keywords: Cardiovascular disease; HIV; Implementation effectiveness; Primary prevention; Risk factors.

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Conflict of interest statement

Statement of conflict of interest

None of the authors have any conflicts of interests with regard to this publication.

Figures

Fig. 1.
Fig. 1.
Implementation using the CFIR.
Fig. 2.
Fig. 2.
Patient subject study flow.
Fig. 3.
Fig. 3.
Project timeline.
See this image and copyright information in PMC

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