Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field

Nick J Willett¹, Michael L Boninger², Laura J Miller³, Luis Alvarez⁴, Tomoki Aoyama⁵, Marzia Bedoni⁶, Kelley Ann Brix⁷, Carmelo Chisari⁸, George Christ⁹, Christopher L Dearth¹⁰, Trevor A Dyson-Hudson¹¹, Christopher H Evans¹², Stephen M Goldman¹⁰, Kenton Gregory¹³, Alice Gualerzi⁶, Joseph Hart¹⁴, Akira Ito⁵, Hiroshi Kuroki⁵, M Terry Loghmani¹⁵, David L Mack¹⁶, Gerard A Malanga¹¹, Linda Noble-Haeusslein¹⁷, Paul Pasquina⁴, Joseph A Roche¹⁸, Lloyd Rose¹⁹, Martin J Stoddart²⁰, Junichi Tajino⁵, Carmen Terzic¹², Kimberly S Topp²¹, William R Wagner²², Stuart J Warden²³, Steven L Wolf²⁴, Hua Xie¹³, Thomas A Rando²⁵, Fabrisia Ambrosio²⁶

Affiliations

¹ Emory University School of Medicine, Atlanta, GA; The Atlanta Veterans Affairs Medical Center, Decatur, GA. Electronic address: nick.willett@emory.edu.
² Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA; VA Pittsburgh Health Care System, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
³ Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
⁴ Uniformed Services University of the Health Sciences, Bethesda, MD.
⁵ Human Health Sciences, Kyoto University, Kyoto, Japan.
⁶ IRCCS Fondazione Don Carlo Gnocchi, Italy.
⁷ Department of Defense Health Agency, Research and Development Directorate, Falls Church, VA.
⁸ University Hospital of Pisa, Italy.
⁹ Departments of Biomedical Engineering and Orthopaedic Surgery, University of Virginia, Charlottesville, VA.
¹⁰ DoD-VA Extremity Trauma and Amputation Center of Excellence, Defense Health Headquarters, Falls Church, VA; Department of Surgery, Uniformed Services University of the Health Sciences - Walter Reed National Military Medical Center, Bethesda, MD.
¹¹ Kessler Foundation, West Orange, NJ; Rutgers New Jersey Medical School, Newark, NJ.
¹² Department of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN.
¹³ Center for Regenerative Medicine, Oregon Health Sciences University, Portland, OR.
¹⁴ Departments of Orthopedic Surgery and Kinesiology, University of Virginia, Charlottesville, VA.
¹⁵ Department of Physical Therapy, School of Health & Human Sciences, Indiana University, Indianapolis, IN.
¹⁶ Rehabilitation Medicine, University of Washington, Seattle, WA.
¹⁷ Departments of Neurology and Psychology and the Institute of Neuroscience, University of Texas at Austin, Austin, TX.
¹⁸ Physical Therapy Program, Department of Health Care Sciences, Wayne State University, Detroit, MI.
¹⁹ Warfighter Expeditionary Medicine and Treatment, U. S. Army Medical Materiel Development Activity, U. S. Army Medical Research and Development Command, Fort Detrick, MD.
²⁰ AO Research Institute Davos, Davos Platz, Switzerland.
²¹ Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA.
²² McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
²³ Department of Physical Therapy, School of Health & Human Sciences, Indiana University, Indianapolis, IN; La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia.
²⁴ Emory University School of Medicine, Atlanta, GA; The Atlanta Veterans Affairs Medical Center, Decatur, GA.
²⁵ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Palo Alto, CA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.
²⁶ Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

PMID: 32035141
PMCID: PMC7576442
DOI: 10.1016/j.apmr.2020.01.007

Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field

Nick J Willett et al. Arch Phys Med Rehabil. 2020 May.

. 2020 May;101(5):917-923.

doi: 10.1016/j.apmr.2020.01.007. Epub 2020 Feb 5.

Authors

Affiliations

¹ Emory University School of Medicine, Atlanta, GA; The Atlanta Veterans Affairs Medical Center, Decatur, GA. Electronic address: nick.willett@emory.edu.
² Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA; VA Pittsburgh Health Care System, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
³ Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA.
⁴ Uniformed Services University of the Health Sciences, Bethesda, MD.
⁵ Human Health Sciences, Kyoto University, Kyoto, Japan.
⁶ IRCCS Fondazione Don Carlo Gnocchi, Italy.
⁷ Department of Defense Health Agency, Research and Development Directorate, Falls Church, VA.
⁸ University Hospital of Pisa, Italy.
⁹ Departments of Biomedical Engineering and Orthopaedic Surgery, University of Virginia, Charlottesville, VA.
¹⁰ DoD-VA Extremity Trauma and Amputation Center of Excellence, Defense Health Headquarters, Falls Church, VA; Department of Surgery, Uniformed Services University of the Health Sciences - Walter Reed National Military Medical Center, Bethesda, MD.
¹¹ Kessler Foundation, West Orange, NJ; Rutgers New Jersey Medical School, Newark, NJ.
¹² Department of Physical Medicine and Rehabilitation, Rehabilitation Medicine Research Center, Mayo Clinic, Rochester, MN.
¹³ Center for Regenerative Medicine, Oregon Health Sciences University, Portland, OR.
¹⁴ Departments of Orthopedic Surgery and Kinesiology, University of Virginia, Charlottesville, VA.
¹⁵ Department of Physical Therapy, School of Health & Human Sciences, Indiana University, Indianapolis, IN.
¹⁶ Rehabilitation Medicine, University of Washington, Seattle, WA.
¹⁷ Departments of Neurology and Psychology and the Institute of Neuroscience, University of Texas at Austin, Austin, TX.
¹⁸ Physical Therapy Program, Department of Health Care Sciences, Wayne State University, Detroit, MI.
¹⁹ Warfighter Expeditionary Medicine and Treatment, U. S. Army Medical Materiel Development Activity, U. S. Army Medical Research and Development Command, Fort Detrick, MD.
²⁰ AO Research Institute Davos, Davos Platz, Switzerland.
²¹ Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA.
²² McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.
²³ Department of Physical Therapy, School of Health & Human Sciences, Indiana University, Indianapolis, IN; La Trobe Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, Victoria, Australia.
²⁴ Emory University School of Medicine, Atlanta, GA; The Atlanta Veterans Affairs Medical Center, Decatur, GA.
²⁵ Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford University, Palo Alto, CA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA.
²⁶ Department of Physical Medicine and Rehabilitation, School of Medicine, University of Pittsburgh, Pittsburgh, PA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA.

PMID: 32035141
PMCID: PMC7576442
DOI: 10.1016/j.apmr.2020.01.007

Abstract

The growing field of regenerative rehabilitation has great potential to improve clinical outcomes for individuals with disabilities. However, the science to elucidate the specific biological underpinnings of regenerative rehabilitation-based approaches is still in its infancy and critical questions regarding clinical translation and implementation still exist. In a recent roundtable discussion from International Consortium for Regenerative Rehabilitation stakeholders, key challenges to progress in the field were identified. The goal of this article is to summarize those discussions and to initiate a broader discussion among clinicians and scientists across the fields of regenerative medicine and rehabilitation science to ultimately progress regenerative rehabilitation from an emerging field to an established interdisciplinary one. Strategies and case studies from consortium institutions-including interdisciplinary research centers, formalized courses, degree programs, international symposia, and collaborative grants-are presented. We propose that these strategic directions have the potential to engage and train clinical practitioners and basic scientists, transform clinical practice, and, ultimately, optimize patient outcomes.

Keywords: Regenerative medicine; Rehabilitation; Tissue engineering.

Published by Elsevier Inc.

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Figures

**Fig 1**
Number of publications by year in the regenerative rehabilitation field. Data from Web of Science search for publications using the terms “Regenerative medicine” AND Rehabilitation; OR “Regenerative Rehabilitation;” OR “Tissue Engineering” AND Rehabilitation (performed on March 6, 2020).

See this image and copyright information in PMC

References

1. U.S. Food and Drug Administration. Framework for the regulation of regenerative medicine products. Available at: https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-produ.... Accessed December 1, 2019.
1. Kelly Scientific Publications. Global regenerative medicine market analysis & forecast to 2023: stem cells, tissue engineering, biobanking & CAR-T industries; 2019. Available at: https://kellysci.com/shop/kelly-scientific-reports/global-regenerative-m.... Accessed December 1, 2019.
1. U.S. National Library of Medicine. Keyword search “Stem Cells”. Available at: https://clinicaltrials.gov/. Accessed April 26, 2019.
1. Turner L, Knoepfler P. Selling stem cells in the USA: assessing the direct-to-consumer industry. Cell Stem Cell 2016;19:154–7. - PubMed
1. Katzmarzyk PT, Janssen I. The economic costs associated with physical inactivity and obesity in Canada: an update. Can J Appl Physiol 2004;29:90–115. - PubMed

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Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field

Affiliations

Taking the Next Steps in Regenerative Rehabilitation: Establishment of a New Interdisciplinary Field

Authors

Affiliations

Abstract

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical