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. 2020 Feb 8;12(3):2545-2583.
doi: 10.18632/aging.102762. Epub 2020 Feb 8.

Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study

Yujiao Deng  1   2 , Meng Wang  1   2 , Linghui Zhou  1   2 , Yi Zheng  1   2 , Na Li  1   2 , Tian Tian  2 , Zhen Zhai  1   2 , Si Yang  1   2 , Qian Hao  2 , Ying Wu  1   2 , Dingli Song  2 , Dai Zhang  2 , Jun Lyu  3 , Zhijun Dai  1   2
Affiliations

Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study

Yujiao Deng et al. Aging (Albany NY). .

Abstract

Larynx cancer is one of the most common cancers in head and neck. This study aimed to investigate the health burden of larynx cancer at global, regional, and national levels. We collected data of larynx cancer between 1990 and 2017 from the Global Burden of Disease study, including incidence, mortality, and disability adjusted life-years (DALYs). Estimated annual percentage changes (EAPCs) were calculated to assess the changes in age-standardized rate (ASR) of larynx cancer. From 1990 to 2017, LC incident cases increased by 58.67%; however, age-standardized incidence rate (ASIR) decreased, with an EAPC of -0.99. Additionally, the incident cases and ASIR of LC were 6-fold higher for male than those for female in 2017. Over the past 28 years, deaths and DALYs of larynx cancer increased by 33.84% and 25%. Contrarily, age-standardized death and DALY rate showed a downward trend. Incidence, death, and DALYs of larynx cancer were always the highest in people aged 50-69 years. Overall, all the ASRs showed downward trends globally. The majority of larynx cancer burden was observed in men, especially among male aged 50-69 years. South and East Asia carried the heaviest burden of larynx cancer worldwide.

Keywords: death; disability adjusted life-years; global burden of disease; incidence; larynx cancer.

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Conflict of interest statement

CONFLICTS OF INTEREST: The authors declare that they have no conflicts of interests.

Figures

Figure 1
Figure 1
The global incidence burden of larynx cancer in 195 countries. (A) The ASIR of larynx cancer in 2017; (B) The relative change in incident cases of larynx cancer between 1990 and 2017; (C) The EAPC of larynx cancer ASIR from 1990 to 2017. Countries with an extreme number of cases/evolution were annotated. ASIR, age-standardized incidence rate; EAPC, estimated annual percentage change.
Figure 2
Figure 2
The EAPC of larynx cancer ASR from 1990 to 2017, by sex and region. (A) The EAPC of ASIR; (B) The EAPC of ASDR; (C) The EAPC of age-standardized DALY rate. ASR: age-standardized rate; ASDR: age standardized death rate; ASIR: age standardized incidence rate; EAPC, estimated annual percentage change; DALY: disability adjusted life-year.
Figure 3
Figure 3
The change trends of age standardized rate among different SDI quintiles and gender from 1990 to 2017. (A) ASIR: age standardized incidence rate; (B) ASDR: age standardized death rate; (C) age-standardized DALY rate. DALY, disability adjusted life-year.
Figure 4
Figure 4
The correlation between EAPC and larynx cancer ASR in 1990 as well as SDI in 2017. The circles represent countries that were available on SDI data. The size of circle is increased with the cases of larynx cancer. The ρ indices and P values presented were derived from Pearson correlation analysis. (A) EAPC and SDI in incidence; (B) EAPC and ASIR; (C) EAPC and SDI in death; (D) EAPC and ASDR; (E) EAPC and SDI in DALYs; (F) EAPC and age-standardized DALY rate. ASIR, age standardized incidence rate; ASDR: age standardized death rate; EAPC, estimated annual percentage change; SDI, socio-demographic index; DALY: disability adjusted life-year.
Figure 5
Figure 5
The proportion of different age groups in larynx cancer by years. (A) incidence, (B) death, (C) DALY. DALY: disability adjusted life-year.
Figure 6
Figure 6
The rate of larynx cancer among gender and age in 1990 and 2017. (A) incidence rate; (B) death rate; (C) DALY rate. DALY, disability adjusted life-year.
See this image and copyright information in PMC

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