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Review
. 2020 Feb 25:318:108973.
doi: 10.1016/j.cbi.2020.108973. Epub 2020 Feb 6.

Carbon monoxide and its donors - Chemical and biological properties

Weronika Adach  1 , Mateusz Błaszczyk  1 , Beata Olas  2
Affiliations
Review

Carbon monoxide and its donors - Chemical and biological properties

Weronika Adach et al. Chem Biol Interact. .

Abstract

Carbon monoxide (CO) is an inorganic chemical compound that can bind with hemoglobin with highly toxic effects. In living organisms, it is produced endogenously during the degradation of heme by oxygenase, which occurs in three isoforms: HO-1, HO-2 and HO-3. CO can play an important role in the regulation of many physiological functions. Carbon Oxide Releasing Molecules (CORMs) are a novel group of chemical compounds capable of controlled CO release directly in tissues or organs. This release depends on concentration, pH, solvent type and temperature. The biological role and the therapeutic potential of different CORMs is not always well demonstrated. However, this mini review summarizes the various function of these compounds.

Keywords: Biological properties; CORM; Carbon monoxide; Chemical.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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