Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency
- PMID: 32036613
- PMCID: PMC7064913
- DOI: 10.5694/mja2.50474
Tafenoquine for the radical cure and prevention of malaria: the importance of testing for G6PD deficiency
Keywords: Anti-infective agents; Malaria.
Conflict of interest statement
Ric Price is a Wellcome Trust Senior Fellow in Clinical Science (200909).
Ric Price was on the expert panel for the tafenoquine licensing application at the US Federal Drug Administration and on the expert committee for the Australian Therapeutic Goods Administration. His travel expenses to the US were reimbursed by GlaxoSmithKline. James McCarthy received funding from 60 Degrees Pharmaceuticals to conduct a randomised controlled trial to test the activity of tafenoquine as a potential drug for the chemoprophylaxis of malaria.
References
-
- Baird JK. Primaquine toxicity forestalls effective therapeutic management of the endemic malarias. Int J Parasitol 2012; 42: 1049–1054. - PubMed
-
- Brueckner RP, Lasseter KC, Lin ET, Schuster BG. First‐time‐in‐humans safety and pharmacokinetics of WR 238605, a new antimalarial. Am J Trop Med Hyg 1998; 58: 645–649. - PubMed
-
- Llanos‐Cuentas A, Lacerda MV, Rueangweerayut R, et al. Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): a multicentre, double‐blind, randomised, phase 2b dose‐selection study. Lancet 2014; 383: 1049–1058. - PubMed
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