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Randomized Controlled Trial
. 2021 Dec;13(1_suppl):1734S-1740S.
doi: 10.1177/1947603520903443. Epub 2020 Feb 10.

Effect of Systematic Exercise Rehabilitation on Patients With Knee Osteoarthritis: A Randomized Controlled Trial

Jing Chao  1 , Zhang Jing  1 , Bai Xuehua  2 , Yang Peilei  3 , Gong Qi  4
Affiliations
Randomized Controlled Trial

Effect of Systematic Exercise Rehabilitation on Patients With Knee Osteoarthritis: A Randomized Controlled Trial

Jing Chao et al. Cartilage. 2021 Dec.

Abstract

Objectives: We aimed to compare the outcomes of exercise rehabilitation and conventional treatment in patients with knee osteoarthritis.

Methods: This trial included a total of 166 patients diagnosed with knee osteoarthritis; they were randomly divided into groups. The experimental group underwent systematic exercise rehabilitation, while the control group received naproxen (n = 28), diclofenac (n = 27), or celecoxib (n = 19). Improvement in symptoms, knee function, and quality of life were compared. SPSS Statistics 24.0 was used for the data analysis.

Results: The mean age of patients was 56.0 ± 10.5 years, and the average follow-up time was 12 ± 2.3 weeks. No statistically significant differences were seen in age, body mass index, and sex (P > 0.05) between the groups. The average Western Ontario and MacMaster Universities (WOMAC) scores after treatment were 84.4 ± 15.2, 108.3 ± 3.9, 107.4 ± 5.4, and 107 ± 6.0 in the exercise rehabilitation, diclofenac, naproxen, and celecoxib groups, respectively. The mean Lysholm scores were 60.3 ± 14.9, 41.0 ± 0.1, 43.5 ± 5.3, and 41.7 ± 3.6 in the exercise rehabilitation, diclofenac, naproxen, and celecoxib groups, respectively. The mean SF-36 (Short Form-36 Survey) scores were 105.4 ± 21.5, 82.5 ± 3.7, 84.2 ± 3.5, and 83.7 ± 5.0 in the exercise rehabilitation, naproxen, celecoxib, and diclofenac groups, respectively. The average ranges of knee motion were 125.0 ± 6.2°, 116.4 ± 1.4°, 114.7 ± 1.1°, and 115.7 ± 0.8° after exercise rehabilitation, diclofenac, naproxen, and celecoxib treatments, respectively. These data presented statistical differences between the groups.

Conclusion: Exercise better improved symptoms and quality of life in patients with knee osteoarthritis over a 12-week follow-up period than that achieved with nonsteroidal anti-inflammatory drugs and COX-2 inhibitors.

Keywords: exercise; knee osteoarthritis; rehabilitation.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram of randomized controlled trial. In this study, we assessed for eligibility 195 cases in enrollment, and finally included 166 cases in analysis; the experiment group included 92 cases, and the control group included 74 cases.
Figure 2.
Figure 2.
Comparison of outcomes experimental group and control group. (A) To investigate whether exercise rehabilitation could reduce symptoms in patients with knee osteoarthritis. (B) To study whether exercise could improve daily life function in patients with knee osteoarthritis. (C) We assessed the life quality of patients with knee osteoarthritis in the short term with exercise rehabilitation and different NASIDs. (D) We examined the knee range of motion in exercise rehabilitation and NASIDs. WOMAC = Western Ontario and McMaster Osteoarthritis Index; SF-36 = Short Form-36 Survey; ROM = knee range of motion.
See this image and copyright information in PMC

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