Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jan 13:19:108-130.
doi: 10.17179/excli2019-1842. eCollection 2020.

The survival rate of hepatocellular carcinoma in Asian countries: a systematic review and meta-analysis

Soheil Hassanipour  1   2 , Mouhebat Vali  3 , Saber Gaffari-Fam  4 , Hossein-Ali Nikbakht  5 , Elham Abdzadeh  1 , Farahnaz Joukar  2   6 , Akram Pourshams  2   7 , Afshin Shafaghi  6 , Mahdi Malakoutikhah  8 , Morteza Arab-Zozani  9   10 , Hamid Salehiniya  9 , Fariborz Mansour-Ghanaei  1   2   6
Affiliations
Review

The survival rate of hepatocellular carcinoma in Asian countries: a systematic review and meta-analysis

Soheil Hassanipour et al. EXCLI J. .

Abstract

Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in Asian countries. The methodology of the present study is based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) statement. The researchers searched five international databases including Medline/PubMed, Scopus, Embase, Web of Knowledge and ProQuest until July 1, 2018. We also searched Google Scholar for detecting grey literature. The Newcastle-Ottawa Quality Assessment Form was used to evaluate the quality of selected papers. A total of 1425 titles were retrieved. 63 studies met the inclusion criteria. Based on the random-effect model one-year, three-year and five-year survival rate of LC were 34.8 % (95 % CI; 30.3-39.3), 19 % (95 % CI ; 18.2-21.8) and 18.1 % (95 % CI ;16.1-20.1) respectively. According to the results of our study, the LC survival rate in Asian countries is relatively lower than in Europe and North America.

Keywords: Asia; hepatocellular carcinoma; meta-analysis; survival rate; systematic review.

PubMed Disclaimer

Figures

Table 1
Table 1. Basic information of included studies
Table 2
Table 2. Result of meta-analysis of survival rate of liver cancer in Asia based on each country and year of survival
Figure 1
Figure 1. Flowchart of the included studies in systematic review
Figure 2
Figure 2. Forest plot of one-year survival rate of liver cancer in Asian countries
Figure 3
Figure 3. Forest plot of three-year survival rate of liver cancer in Asian countries
Figure 4
Figure 4. Forest plot of five-year survival rate of liver cancer in Asian countries
Figure 5
Figure 5. Forest plot of ten-year survival rate of liver cancer in Asian countries
See this image and copyright information in PMC

References

    1. Agarwal A, Yadav AK, Kumar A, Gupta S, Panwala HK, Redhu N, et al. Transarterial chemoembolization in unresectable hepatocellular carcinoma--assessing the factors affecting the survival: An audit from a tertiary care center in northern india. Indian J Gastroenterol. 2015;34:117–126. - PubMed
    1. Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, et al. Global surveillance of trends in cancer survival 2000-14 (concord-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 2018;391:1023–1075. - PMC - PubMed
    1. Altekruse SF, Henley SJ, Cucinelli JE, McGlynn KA. Changing hepatocellular carcinoma incidence and liver cancer mortality rates in the united states. Am J Gastroenterol. 2014;109:542–553. - PMC - PubMed
    1. Altekruse SF, McGlynn KA, Reichman ME. Hepatocellular carcinoma incidence, mortality, and survival trends in the united states from 1975 to 2005. J Clin Oncol. 2009;27:1485–1491. - PMC - PubMed
    1. Aniaku JK, Amedonu EK, Fusheini A. Assessment of knowledge, attitude and vaccination status of hepatitis b among nursing training students in ho, ghana. Ann Global Health. 2019;85(1) - PMC - PubMed

LinkOut - more resources