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. 2008 Sep;24(3):189-194.
doi: 10.5487/TR.2008.24.3.189. Epub 2008 Sep 1.

Effects of DHU001, a Mixed Herbal Formula on Acute Inflammation in Mice

Young-Doo Back  1 , Hyeung-Sik Lee  1 , Sae-Kwang Ku  2
Affiliations

Effects of DHU001, a Mixed Herbal Formula on Acute Inflammation in Mice

Young-Doo Back et al. Toxicol Res. 2008 Sep.

Abstract

The effects of DHU001, a mixed herbal formula consisted of 7 types aqueous extracts for treating respiratory disorders were observed on xylene-induced acute inflammation. The xylene was topically applied 60 min after administration of 500, 250 and 125 mg/kg of DHU001, and all animals were sacrificed 2 hrs after xylene application. The changes on ear weights, histolopathological analyses of ear were evaluated and compared to those of indomethacin and dexamethasone (15 mg/kg treated) - Both of drugs are well-known by anti-inflammatory agents. Xylene application resulted in marked increases in induced ear weights as compared with intact control ear. Severe vasodilation, edematous changes of ear skin and increase in the thickness of the ear tissues, neutrophil infiltration as acute inflammation were detected in xylene-treated control ears at histopathological observation. However, these xylene-induced acute inflammatory changes were dose-dependently decreased by oral treatment of DHU001. Therefore, it is concluded that DHU001 has favorable anti-inflammatory effects on xylene-applicated acute ear inflamed mice.

Keywords: Acute inflammation; DHU001; Histology; Mixed herbal formula; Mouse.

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References

    1. Ahn KS, Noh EJ, Zhao HL, Jung SH, Kang SS, Kim YS. Inhibition of inducible nitric oxide synthase and cyclooxygenase II by Platycodon grandiflorum saponins via suppression of nuclear factor-kappaB activation in RAW 264.7 cells. Life Sci. 2005;76:2315–2328. doi: 10.1016/j.lfs.2004.10.042. - DOI - PubMed
    1. Aimbire F, Penna SC, Rodrigues M, Rodrigues KC, Lopes-Martins RA, Sertie JA. Effect of hydroalcoholic extract of Zingiber officinalis rhizomes on LPS-induced rat airway hyperreactivity and lung inflammation. Prostaglandins Leukot Essent Fatty Acids. 2007;77:129–138. doi: 10.1016/j.plefa.2007.08.008. - DOI - PubMed
    1. AI-Majed A A, Khattab M, Raza M, AI-Shabanah OA, Mostafa AM. Potentiation of diclofenacinduced anti-inflammatory response by aminoguanidine in carrageenan- induced acute inflammation in rats: the role of nitric oxide. Inflamm. Res. 2003;52:378–382. doi: 10.1007/s00011-003-1189-1. - DOI - PubMed
    1. Amin AR, Vyas P, Attur M, Leszczynska-Piziak J, Patel IR, Weissmann G, Abramson SB. The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc. Natl. Acad. Sci. USA. 1995;92:7926–7930. doi: 10.1073/pnas.92.17.7926. - DOI - PMC - PubMed
    1. Baliga MS, Jagetia GC, Rao SK, Babu K. Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Nahrung. 2003;47:261–264. doi: 10.1002/food.200390061. - DOI - PubMed

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