Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2019 Dec;8(Suppl 4):S430-S434.
doi: 10.21037/tlcr.2019.11.08.

Molecular studies of lung neuroendocrine neoplasms uncover new concepts and entities

Lynnette Fernandez-Cuesta  1 , Matthieu Foll  1
Affiliations
Editorial

Molecular studies of lung neuroendocrine neoplasms uncover new concepts and entities

Lynnette Fernandez-Cuesta et al. Transl Lung Cancer Res. 2019 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Summary overview of current knowledge and proposal for a G3 lung NET group. The carcinoid-like LCNEC samples, currently classified as LCNEC, might correspond to G3 lung NETs. In his recent study, Simbolo and colleagues (12) validated the existence of most of the LCNEC and carcinoid molecular groups represented here. G1/2/3, grade 1/2/3; SCLC, small cell lung carcinoma; LCNEC, large-cell neuroendocrine carcinoma; Supra-ca, supra-carcinoids; Carc. A/B, Carcinoids A/B; NE, neuroendocrine; CRG, chromatin-remodeling genes.
See this image and copyright information in PMC

Comment on

References

    1. Rindi G, Klimstra DS, Abedi-Ardekani B, et al. A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal. Mod Pathol 2018;31:1770-86. 10.1038/s41379-018-0110-y - DOI - PMC - PubMed
    1. Travis WD. Advances in neuroendocrine lung tumors. Ann Oncol 2010;21 Suppl 7:vii65-71. 10.1093/annonc/mdq380 - DOI - PubMed
    1. Wolin EM. Advances in the Diagnosis and Management of Well-Differentiated and Intermediate-Differentiated Neuroendocrine Tumors of the Lung. Chest 2017;151:1141-6. 10.1016/j.chest.2016.06.018 - DOI - PubMed
    1. Travis WD, Brambilla E, Nicholson AG, et al. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advances Since the 2004 Classification. J Thorac Oncol 2015;10:1243-60. 10.1097/JTO.0000000000000630 - DOI - PubMed
    1. Swarts DR, Ramaekers FC, Speel EJ. Molecular and cellular biology of neuroendocrine lung tumors: evidence for separate biological entities. Biochim Biophys Acta 2012;1826:255-71. - PubMed