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Meta-Analysis
. 2021 Jan;30(1):84-96.
doi: 10.1097/CEJ.0000000000000578.

The association between hypertension and colorectal cancer: a meta-analysis of observational studies

Kun Xuan  1 , Tianming Zhao  1 , Chenyu Sun  2 , Akash S Patel  3 , Haixia Liu  1 , Xin Chen  1 , Guangbo Qu  1 , Yehuan Sun  1   4
Affiliations
Meta-Analysis

The association between hypertension and colorectal cancer: a meta-analysis of observational studies

Kun Xuan et al. Eur J Cancer Prev. 2021 Jan.

Abstract

The relationship between hypertension and risk of colorectal cancer (CRC) is unclear. This meta-analysis aims to explore the association between them. Six databases were searched for studies published before August 2019. The pooled relative risk (RR) and 95% confidence intervals (CIs) were calculated to estimate the association between the hypertension and CRC risk. A total of 2841 potentially relevant articles were obtained, and 25 studies with a pooled 1.95 million participants were finally included in the meta-analysis. These results suggested a positive association between hypertension and risk of CRC with a pooled RR of 1.15 (95% CI: 1.08, 1.23). Male patients with hypertension had a 13% (95% CI: 1.06, 1.20) increased risk of CRC. The risk of colon cancer and rectal cancer in male patients was 1.17 (95% CI: 1.01, 1.36) and 1.35 (95% CI: 1.04, 1.74), respectively, while no association between hypertension and the risk of CRC in females was elucidated. This meta-analysis demonstrated that a positive association between hypertension and CRC exists, with male patients having a higher risk of developing CRC than female patients.

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References

    1. Adamu UG, Okuku GA, Oladele CO, Abdullahi A, Oduh JI, Fasae AJ. Serum lipid profile and correlates in newly presenting Nigerians with arterial hypertension. Vasc Health Risk Manag. 2013; 9:763–768
    1. Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR. The metabolic syndrome and risk of incident colorectal cancer. Cancer. 2006; 107:28–36
    1. Bardou M, Barkun AN, Martel M. Obesity and colorectal cancer. Gut. 2013; 62:933–947
    1. Bloch MJ. Worldwide prevalence of hypertension exceeds 1.3 billion. J Am Soc Hypertens. 2016; 10:753–754
    1. Bowers K, Albanes D, Limburg P, Pietinen P, Taylor PR, Virtamo J, Stolzenberg-Solomon R. A prospective study of anthropometric and clinical measurements associated with insulin resistance syndrome and colorectal cancer in male smokers. Am J Epidemiol. 2006; 164:652–664

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