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Editorial
. 2020 Feb 6;34(5-6):251-253.
doi: 10.1101/gad.336420.120. Online ahead of print.

PARPs and ADP-ribosylation: 60 years on

W Lee Kraus  1
Affiliations
Editorial

PARPs and ADP-ribosylation: 60 years on

W Lee Kraus. Genes Dev. .

Abstract

Work on PARPs-a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins-has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.

Keywords: ADP-ribosylation; PARPs; posttranslational modification.

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