Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2020 Jan 4;12(1):e6559.
doi: 10.7759/cureus.6559.

Rhesus Isoimmunization: Late-onset Hemolytic Disease of the Newborn Without Jaundice

Maryam Haider  1 , Snober Memon  2 , Fizza Tariq  3 , Sara Fatima  4 , Ammara Hameed  5
Affiliations
Case Reports

Rhesus Isoimmunization: Late-onset Hemolytic Disease of the Newborn Without Jaundice

Maryam Haider et al. Cureus. .

Abstract

Rhesus (Rh) isoimmunization commonly presents with anemia and jaundice of varying intensity in the early postnatal period and is usually treated with phototherapy and exchange transfusion. Rarely, babies with mild or no symptoms at birth may present later with severe hemolytic anemia. This report describes a newborn infant with no postnatal jaundice who presented during the second week of life with severe anemia. These findings indicate the importance of regular follow-up and close monitoring of Rh-isoimmunized infants during the first two months of life for delayed onset anemia.

Keywords: anemia; blood transfusion; direct coombs test; hdn; jaundice; newborn; phototherapy; rh isoimmunization.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Appropriate provision of anti-D prophylaxis to RhD negative pregnant women: a scoping review. Fyfe TM, Ritchey MJ, Taruc C, Crompton D, Galliford B, Perrin R. BMC Pregnancy Childbirth. 2014;14:411. - PMC - PubMed
    1. Rh-immunoglobulin: Rh prophylaxis. Bowman J. Best Pract Res Clin Haematol. 2006;19:27–34. - PubMed
    1. Management of the Rh-sensitized mother. Gollin YG, Copel JA. Clin Perinatol. 1995;22:545–559. - PubMed
    1. RhD haemolytic disease of the fetus and the newborn. Urbaniak SJ, Greiss MA. Blood Rev. 2000;14:44–61. - PubMed
    1. Rhesus isoimmunization: increased hemolysis during early infancy. Hayde M, Widness JA, Pollak A, Kohlhauser-Vollmuth C, Vreman HJ, Stevenson DK. Pediatr Res. 1997;41:716–721. - PubMed

Publication types

LinkOut - more resources