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. 2019 Dec;7(23):722.
doi: 10.21037/atm.2019.12.25.

Maternal serum pentraxin 3 level in early pregnancy for prediction of gestational diabetes mellitus

Xiaoxian Qu  1 , Jingyi Zhuang  1 , Chuanlu Xu  1 , Zisheng Ai  2 , Ling Yuan  1 , Yuping Tang  1 , Qun Shu  1 , Yirong Bao  1 , Huan Han  1 , Hao Ying  1
Affiliations

Maternal serum pentraxin 3 level in early pregnancy for prediction of gestational diabetes mellitus

Xiaoxian Qu et al. Ann Transl Med. 2019 Dec.

Abstract

Background: Our study aimed to reveal the relationship of maternal pentraxin 3 (PTX3)'s serum concentrations in early pregnancy with gestational diabetes mellitus (GDM) and to explore its potential in the prediction of GDM.

Methods: Totally 824 pregnant women were enrolled and divided into a GDM group and a normal glucose tolerance (NGT) group, whose maternal fasting serum PTX3 levels, plasma glucose and insulin were collected. The beta cell function index and quantitative insulin sensitivity check index (QUICKI) was calculated and a homeostatic model assessment of insulin resistance (HOMA-IR) was used with SPSS 22 software used for statistical analysis.

Results: Of all subjects, 13.59% developed GDM. Compared to the NGT group, the PTX3 level was increased in the GDM group (1.48 vs. 1.52 ng/mL, P<0.05), and independently associated with the prediction of GDM (4.209, 95% CI, 1.756-10.091) (P=0.001). The area under receiver operating characteristic curve (AUROC) of the combined screening of PTX3 for GDM was incremented to 0.657 by the addition of maternal characteristics, and it reached a maximum of 0.743 in further combination with biochemical markers.

Conclusions: Serum PTX3 levels in early pregnancy may provide a useful approach for early prediction of GDM.

Keywords: Gestational diabetes mellitus (GDM); pentraxin 3 (PTX3); prediction.

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Flow diagram summarizing selection of patients.
Figure 2
Figure 2
ROC curves of different combination screening for GDM. H.F., HbA1c and FINS; M.C., maternal characteristics (maternal age ≥35 years old, first-degree relative history of diabetes). PTX3, pentraxin 3; GDM, gestational diabetes mellitus.
See this image and copyright information in PMC

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