Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Dec;7(23):749.
doi: 10.21037/atm.2019.11.70.

The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

Xiaosheng Huang  1   2 , Yunping Xu  3 , Wenchieh Chen  2 , Tianhui Zhu  1   2 , Liumei He  3 , Songxing Wang  3 , Shiming Peng  1   2 , Shaoyi Mei  1   2 , Yan Wang  2 , Jun Zhao  1   2
Affiliations

The genetic contribution of HLA-E*01:03 and HLA-E*01:03-G*01:01 to Posner-Schlossman syndrome in southern Chinese

Xiaosheng Huang et al. Ann Transl Med. 2019 Dec.

Abstract

Background: The polymorphisms of classical HLA-Ia and HLA-II loci have been associated with Posner-Schlossman syndrome (PSS) in the southern Chinese population. However, the associations of non-classical HLA-Ib (e.g., HLA-E and HLA-G) loci with PSS have not been reported for in the southern Chinese population. This study aimed to evaluate the associations of the HLA-E and HLA-G loci with PSS in a southern Chinese Han population group.

Methods: Ninety-seven unrelated patients with PSS and 90 ethnically matched control subjects were recruited from the Shenzhen Eye Hospital in China. The full-length sequences of HLA-E and HLA-G genes were amplified by long-range high-fidelity PCR, and the third exon of the HLA-E gene and the coding region of the HLA-G gene were sequenced.

Results: The allele frequency of HLA-E*01:03 in patients with PSS was significantly higher than that in the control group (P=0.017, corrected P=0.034, OR =1.66). The genotype frequencies of HLA-E*01:01/01:03 and HLA-E*01:03/01:03 in the PSS group were significantly higher than that in the control group (P=0.027, OR =2.62; P=0.011, OR =3.05; respectively). There were no significant differences in the frequency of HLA-G alleles and genotypes between the two groups (all P>0.05). The haplotype frequency of HLA-E*01:03-G*01:01 in the PSS group was significantly higher than that in the control group (P=0.019, OR =1.63), although this association did not survive the Bonferroni correction (corrected P=0.13).

Conclusions: This study proved for the first time that HLA-E*01:03 and HLA-E*01:03-G*01:01 might be risk factors for PSS.

Keywords: Chinese; HLA-E; HLA-G; Posner-Schlossman syndrome (PSS); genetic association.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Posner A, Schlossman A. Syndrome of unilateral recurrent attacks of glaucoma with cyclitic symptoms. Arch Ophthal 1948;39:517-35. 10.1001/archopht.1948.00900020525007 - DOI - PubMed
    1. Jiang JH, Zhang SD, Dai ML, et al. Posner-Schlossman syndrome in Wenzhou, China: a retrospective review study. Br J Ophthalmol 2017;101:1638-42. 10.1136/bjophthalmol-2016-309863 - DOI - PubMed
    1. Megaw R, Agarwal PK. Posner-Schlossman syndrome. Surv Ophthalmol 2017;62:277-85. 10.1016/j.survophthal.2016.12.005 - DOI - PubMed
    1. Maruyama K, Maruyama Y, Sugita S, et al. Characteristics of cases needing advanced treatment for intractable Posner-Schlossman syndrome. BMC Ophthalmol 2017;17:45. 10.1186/s12886-017-0438-y - DOI - PMC - PubMed
    1. Alifu M, Chang X, Kuerban G, et al. Distribution of HLA-A alleles and its relation to clinical outcome in Uyghur and Han patients with advanced squamous cell cervical cancer in Xinjiang, China. Transl Cancer Res 2018;7:220-30. 10.21037/tcr.2018.01.27 - DOI