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. 2019 Dec;8(4):167-170.
doi: 10.22099/mbrc.2019.34904.1438.

Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Nikhil Kirtipal  1   2 , Hitender Thakur  1   2 , Ranbir Chander Sobti  1
Affiliations

Insertion/deletion polymorphism of angiotensin-converting enzyme and chronic obstructive pulmonary disease: A case-control study on north Indian population

Nikhil Kirtipal et al. Mol Biol Res Commun. 2019 Dec.

Abstract

This research aimed to explore the ACE (insertion/deletion) gene association as key factor for chronic obstructive pulmonary disease (COPD) development in north Indian population. A total of 200 clinically diagnosed patients with COPD were selected against 200 healthy individuals. Genetic variations of ACE (insertion/deletion) were evaluated by using polymerase chain reaction techniques. Smoker showed higher risk of COPD (OR=1.67, 95% CI=1.12-2.48, P=0.012). Present results revealed the positive association between the DD genotype and the risk of COPD (OR= 2.14, 95% CI=1.22-3.78, P=0.006). Among smokers, DD genotype showed statistically significant association with increased risk of COPD (OR=3.10, 95% CI= 1.50-6.47, P=0.001).

Keywords: ACE; COPD; Genotype; Polymorphism.

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Conflict of interest statement

The authors have declared no conflict of interest.

References

    1. Busquets X, MacFarlane NG, Heine-Suner D, Morla M, Torres-Juan L, Iglesias A, Llado J, Sauleda J, Agusti AG. Angiotensin-converting-enzyme gene polymorphisms, smoking and chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2007;2:329–334. - PMC - PubMed
    1. Rigat B, Hubert C, Corvol P, Soubrier F. PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxy peptidase 1) Nucleic Acids Res. 1992;20:1433. - PMC - PubMed
    1. Ma Y, Tong X, Liu Y, Liu S, Xiong H, Fan H. ACE gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis. Int J Chron Obstruct Pulmon Dis. 2018;13:2435–2446. - PMC - PubMed
    1. Studdy PR, Lapworth R, Bird R. Angiotensin-converting enzyme and its clinical significance - a review. J Clin Pathol. 1983;36:938–947. - PMC - PubMed
    1. Vasileiadis IE , Goudis CA , Giannakopoulou PT , Liu T Angiotensin converting enzyme inhibitors and angiotensin receptor blockers: A promising medication for chronic obstructive pulmonary disease? COPD. 2018:148–156. - PubMed

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