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. 2020 Jan 21;7(2):ofaa011.
doi: 10.1093/ofid/ofaa011. eCollection 2020 Feb.

Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak

Marco Falcone  1 , Giusy Tiseo  1 , Alberto Antonelli  2 , Cesira Giordano  3 , Vincenzo Di Pilato  2 , Pietro Bertolucci  4 , Eva Maria Parisio  5 , Alessandro Leonildi  4 , Noemi Aiezza  2 , Ilaria Baccani  2 , Enrico Tagliaferri  6 , Lorenzo Righi  7 , Silvia Forni  8 , Spartaco Sani  9 , Maria Teresa Mechi  7 , Filippo Pieralli  10 , Simona Barnini  3 , Gian Maria Rossolini  2   11 , Francesco Menichetti  1
Affiliations

Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase-Producing Enterobacterales During a Regional Outbreak

Marco Falcone et al. Open Forum Infect Dis. .

Abstract

Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.

Keywords: New Delhi metallo-β-lactamases; bacteremia; carbapenem-resistant.

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References

    1. European Centre for Disease Control and Prevention. Regional outbreak of New Delhi metallo-beta-lactamase-producing carbapenem-resistant Enterobacteriaceae, Italy, 2018–2019 June 2019. Available at: https://ecdc.europa.eu/sites/portal/files/documents/04-Jun-2019-RRA-Carb.... Accessed 10 December 2019.
    1. Falcone M, Russo A, Iacovelli A, et al. . Predictors of outcome in ICU patients with septic shock caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae. Clin Microbiol Infect 2016; 22:444–50. - PubMed
    1. Singer M, Deutschman CS, Seymour CW, et al. . The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016; 315:801–10. - PMC - PubMed
    1. Antonelli A, Arena F, Giani T, et al. . Performance of the BD MAX™ instrument with Check-Direct CPE real-time PCR for the detection of carbapenemase genes from rectal swabs, in a setting with endemic dissemination of carbapenemase-producing Enterobacteriaceae. Diagn Microbiol Infect Dis 2016; 86:30–4. - PubMed
    1. International Organization for Standardization, Clinical laboratory testing and in vitro diagnostic test systems. Susceptibility testing of infectious agents and evaluation of performance of antimicrobial susceptibility test devices—part 1: reference method for testing the in vitro activity of antimicrobial agents against rapidly growing aerobic bacteria involved in infectious diseases ISO 20776-1:2019. Available at: https://www.iso.org/standard/70464.html. Accessed on 18 January 2020.