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. 2020 Feb 1;5(1):21-22.
doi: 10.1016/j.synbio.2020.01.002. eCollection 2020 Mar.

Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Bin Wang  1 , Huimin Zhao  1   2   3   4   5
Affiliations

Unleashing the power of energy storage: Engineering β-oxidation pathways for polyketide production

Bin Wang et al. Synth Syst Biotechnol. .

Erratum in

  • Erratum regarding previously published articles.
    [No authors listed] [No authors listed] Synth Syst Biotechnol. 2020 Oct 14;5(4):332. doi: 10.1016/j.synbio.2020.10.004. eCollection 2020 Dec. Synth Syst Biotechnol. 2020. PMID: 33102828 Free PMC article.

Abstract

Overproduction of polyketides has been a challenge for metabolic engineering for decades. However, recent studies have demonstrated that in both native host and heterologous host, engineering β -oxidation pathways can lead to dramatic improvement of polyketide production.

Keywords: Beta-oxidation pathway; Metabolic engineering; Polyketide; Triacylglycerols.

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Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Metabolic engineering of β-oxidation pathways in Y. lipolytica and Streptomyces hosts for polyketide production. Abbreviations: TAG, triacylglycerol; ACS, fatty acid CoA synthetase.
See this image and copyright information in PMC

References

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