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. 2020 Jan 27;18(1):57-64.
doi: 10.18502/ijrm.v18i1.6201. eCollection 2019 Apr.

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Fatemeh Sadat Najib  1 , Tahereh Poordast  1 , Mina Rezvan Nia  1 , Mohammad Hossein Dabbaghmanesh  2
Affiliations

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Fatemeh Sadat Najib et al. Int J Reprod Biomed. .

Abstract

Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).

Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.

Materials and methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100µg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.

Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).

Conclusion: The results of this trial suggest that supplementation with 100µg of selenium does not modulate glucose homeostasis in women with GDM.

Keywords: Gestational; Selenium.; Diabetes.

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Conflict of interest statement

None of the co-authors have any financial or another relevant conflict of interest in the material covered by the manuscript.

Figures

Figure 1
Figure 1
Consort 2010 flow diagram.
Figure 2
Figure 2
The changing flow of FPG for each group.
See this image and copyright information in PMC

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