Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan 27;18(1):57-64.
doi: 10.18502/ijrm.v18i1.6201. eCollection 2019 Apr.

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Fatemeh Sadat Najib  1 , Tahereh Poordast  1 , Mina Rezvan Nia  1 , Mohammad Hossein Dabbaghmanesh  2
Affiliations

Effects of selenium supplementation on glucose homeostasis in women with gestational diabetes mellitus: A randomized, controlled trial

Fatemeh Sadat Najib et al. Int J Reprod Biomed. .

Abstract

Background: There is limited evidence about the anti-diabetic effects of selenium supplementation in women with gestational diabetes mellitus (GDM).

Objective: This study investigates the effects of selenium supplementation on glucose homeostasis in women with GDM.

Materials and methods: A total of 60 pregnant women with GDM were enrolled in this prospective randomized, double-blind, and placebo-controlled clinical trial. They were randomly assigned to take either 100µg selenium supplements as tablet or a placebo daily for 12 wk since 24-28 wk of gestation. The primary outcomes were changes in the glucose homeostasis, including fasting plasma glucose, the 2-hr post prandial blood glucose, serum insulin level, glycosylated hemoglobin (Hb A1C), and the homeostasis model assessment of insulin resistance(HOMA_IR) at the initial period and 3 months after intervention.

Results: The mean maternal age of the patients who took selenium supplements was 29.19 ± 6.16 (range 18-41) years. In the placebo group, the mean maternal age was 31 ± 4.43 (range 24-39) years. Compared with the placebo group, fasting plasma glucose, 2-hr post-prandial blood glucose, glycosylated hemoglobin(Hb A1C), serum insulin level, and homeostasis model of assessment-estimated insulin resistance(HOMA_IR) were not significantly changed in the selenium group at the end of study (p = 0.25, p = 0.87, p = 0.34, p = 0.57, and p = 0.31, respectively).

Conclusion: The results of this trial suggest that supplementation with 100µg of selenium does not modulate glucose homeostasis in women with GDM.

Keywords: Gestational; Selenium.; Diabetes.

PubMed Disclaimer

Conflict of interest statement

None of the co-authors have any financial or another relevant conflict of interest in the material covered by the manuscript.

Figures

Figure 1
Figure 1
Consort 2010 flow diagram.
Figure 2
Figure 2
The changing flow of FPG for each group.
See this image and copyright information in PMC

References

    1. Buchanan T. A., Xiang A. H. Gestational diabetes mellitus. The Journal of Clinical Investigation. 2005;115(3):485–491. doi: 10.1172/JCI200524531. - DOI - PMC - PubMed
    1. Harlev A., Wiznitzer A. New Insights on Glucose Pathophysiology in Gestational Diabetes and Insulin Resistance. Current Diabetes Reports. 2010;10(3):242–247. doi: 10.1007/s11892-010-0113-7. - DOI - PubMed
    1. Coustan D. R. Gestational Diabetes Mellitus. Clinical Chemistry. 2013;59(9):1310–1321. doi: 10.1373/clinchem.2013.203331. - DOI - PubMed
    1. Chen X., Scholl T. O., Leskiw M. J., Donaldson M. R., Stein T. P. Association of Glutathione Peroxidase Activity with Insulin Resistance and Dietary Fat Intake during Normal Pregnancy. The Journal of Clinical Endocrinology & Metabolism. 2003;88(12):5963–5968. doi: 10.1210/jc.2003-030544. - DOI - PubMed
    1. Ghaemi S. Z., Forouhari S., Dabbaghmanesh M. H., Sayadi M., Bakhshayeshkaram M., Vaziri F., Tavana Z. A Prospective Study of Selenium Concentration and Risk of Preeclampsia in Pregnant Iranian Women: a Nested Case–Control Study. Biological Trace Element Research. 2013;152(2):174–179. doi: 10.1007/s12011-013-9614-y. - DOI - PubMed

LinkOut - more resources