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. 2020 Apr;102(4):876-879.
doi: 10.4269/ajtmh.19-0593.

Absence of Evidence of Zika Virus Infection in Cord Blood and Urine from Newborns with Congenital Abnormalities, Indonesia

Nina Dwi Putri  1 , Rama Dhenni  2 , Setyo Handryastuti  1 , Edison Johar  2 , Chairin Nisa Ma'roef  2 , Araniy Fadhilah  2 , Adhi Teguh Perma Iskandar  1 , Ari Prayitno  1 , Mulya Rahma Karyanti  1 , Hindra Irawan Satari  1 , Niphidiah Jumiyanti  1 , Yuni Yudha Aprilia  1 , Ida Yus Sriyani  2 , Yora Permata Dewi  2 , Frilasita A Yudhaputri  2 , Dodi Safari  2 , Sri Rezeki Hadinegoro  1 , Ronald Rosenberg  3 , Ann M Powers  3 , Khin Saw Aye Myint  2
Affiliations

Absence of Evidence of Zika Virus Infection in Cord Blood and Urine from Newborns with Congenital Abnormalities, Indonesia

Nina Dwi Putri et al. Am J Trop Med Hyg. 2020 Apr.

Abstract

Zika virus (ZIKV) has recently been confirmed as endemic in Indonesia, but no congenital anomalies (CA) related to ZIKV infection have been reported. We performed molecular and serological testing for ZIKV and other flaviviruses on cord serum and urine samples collected in October 2016 to April 2017 during a prospective, cross-sectional study of neonates in Jakarta, Indonesia. Of a total of 429 neonates, 53 had CA, including 14 with microcephaly. These 53, and 113 neonate controls without evidence of CA, were tested by ZIKV-specific real-time reverse transcription polymerase chain reaction (RT-PCR), pan-flavivirus RT-PCR, anti-ZIKV and anti-DENV IgM ELISA, and plaque reduction neutralization test. There was no evidence of ZIKV infection among neonates in either the CA or non-CA cohorts, except in three cases with low titers of anti-ZIKV neutralizing antibodies. Further routine evaluation throughout Indonesia of pregnant women and their newborns for exposure to ZIKV should be a high priority for determining risk.

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Conflict of interest statement

Disclosure: The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the U.S. Centers for Disease Control and Prevention.

Figures

Figure 1.
Figure 1.
Study flowchart of patient enrollment and sample collection.
See this image and copyright information in PMC

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