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Comment
. 2020 Feb;25(2):e396-e397.
doi: 10.1634/theoncologist.2019-0515. Epub 2019 Nov 6.

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Blake Warner et al. Oncologist. 2020 Feb.

Abstract

This letter to the editor is in response to the letter from Brugu's and colleagues regarding the Warner et al. study of sicca syndrome induced by immune checkpoint inhibitor therapy.

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Figures

Figure 1
Figure 1
Some patients with immune checkpoint‐induced sicca experienced objective improvements in saliva flow (4/9) using a graded approach as described in Warner et al. 2. However, even with modest objective improvement in saliva flow, all patients remained CTCAE grade 3 using objective criteria for “dry mouth.”

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References

    1. Ortiz Brugués A, Sibaud V, Herbault‐Barrés B et al. Sicca syndrome induced by immune checkpoint inhibitor therapy: Optimal management still pending. The Oncologist 2020;25:e391–e395. - PMC - PubMed
    1. Warner BM, Baer AN, Lipson EJ et al. Sicca syndrome associated with immune checkpoint inhibitor therapy. The Oncologist 2019;24:1259–1269. - PMC - PubMed
    1. Burbelo PD, Ferré EMN, Chaturvedi A et al. Profiling autoantibodies against salivary proteins in sicca conditions. J Dent Res 2019. Jul;98:772–778. - PMC - PubMed
    1. Arbour KC, Mezquita L, Long N et al. Impact of baseline steroids on efficacy of programmed cell death‐1 and programmed death‐ligand 1 blockade in patients with non‐small‐cell lung cancer. J Clin Oncol 2018;36:2872–2878. - PubMed
    1. Ricciuti B, Dahlberg SE, Adeni A et al. Immune checkpoint inhibitor outcomes for patients with non‐small‐cell lung cancer receiving baseline corticosteroids for palliative versus nonpalliative indications. J Clin Oncol 2019;37:1927–1934. - PubMed