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. 2020 Feb;25(2):91-93.
doi: 10.1634/theoncologist.2019-0464. Epub 2019 Nov 19.

Statistical Test/Estimation Methods Used in Contemporary Phase III Cancer Randomized Controlled Trials with Time-to-Event Outcomes

Hajime Uno  1   2 , Miki Horiguchi  1 , Michael J Hassett  1
Affiliations

Statistical Test/Estimation Methods Used in Contemporary Phase III Cancer Randomized Controlled Trials with Time-to-Event Outcomes

Hajime Uno et al. Oncologist. 2020 Feb.

Abstract

There exist a wide variety of statistical methods for clinical trials. Despite decades of clinical trial research, little is known about which methods are used in data analysis practice of the real world. This review describes the evidence of existing practices on survival data analysis and identifies potential opportunities to improve them.

Keywords: Interpretability; Robustness; Survival data analysis; Test/estimation coherency; Treatment decision making.

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Conflict of interest statement

Disclosures of potential conflicts of interest may be found at the end of this article.

Figures

Figure 1
Figure 1
Disposition of papers. “Not primary manuscript” includes ad hoc subgroup analyses, reports of correlative studies (e.g., quality of life data), reports of analysis of prognostic factors, prediction modeling, results of long‐term follow‐up data, and so on. Abbreviations: DFS, disease‐free survival; OS, overall survival; PFS, progression‐free survival.
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