Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

doi:10.1016/S0140-6736(20)30317-2

. 2020 Feb 15;395(10223):473-475.

doi: 10.1016/S0140-6736(20)30317-2. Epub 2020 Feb 7.

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

Clark D Russell¹, Jonathan E Millar², J Kenneth Baillie³

Affiliations

¹ University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute Edinburgh, Edinburgh, UK.
² Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
³ Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK. Electronic address: j.k.baillie@ed.ac.uk.

PMID: 32043983
PMCID: PMC7134694
DOI: 10.1016/S0140-6736(20)30317-2

Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

Clark D Russell et al. Lancet. 2020.

. 2020 Feb 15;395(10223):473-475.

doi: 10.1016/S0140-6736(20)30317-2. Epub 2020 Feb 7.

Authors

Clark D Russell¹, Jonathan E Millar², J Kenneth Baillie³

Affiliations

¹ University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute Edinburgh, Edinburgh, UK.
² Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK.
³ Genetics and Genomics, Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, UK. Electronic address: j.k.baillie@ed.ac.uk.

PMID: 32043983
PMCID: PMC7134694
DOI: 10.1016/S0140-6736(20)30317-2

No abstract available

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Comment in

On the use of corticosteroids for 2019-nCoV pneumonia.
Shang L, Zhao J, Hu Y, Du R, Cao B. Shang L, et al. Lancet. 2020 Feb 29;395(10225):683-684. doi: 10.1016/S0140-6736(20)30361-5. Epub 2020 Feb 12. Lancet. 2020. PMID: 32122468 Free PMC article. No abstract available.
Corticosteroid use for 2019-nCoV infection: A double-edged sword.
Nasim S, Kumar S, Azim D, Ashraf Z, Azeem Q. Nasim S, et al. Infect Control Hosp Epidemiol. 2020 Oct;41(10):1244-1245. doi: 10.1017/ice.2020.165. Epub 2020 Apr 23. Infect Control Hosp Epidemiol. 2020. PMID: 32321620 Free PMC article. No abstract available.
Contrasting evidence for corticosteroid treatment for coronavirus-induced cytokine storm.
Leung KKY, Hon KL, Qian SY, Cheng FWT. Leung KKY, et al. Hong Kong Med J. 2020 Jun;26(3):269-271. doi: 10.12809/hkmj208517. Epub 2020 Jun 5. Hong Kong Med J. 2020. PMID: 32536610 No abstract available.

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References

1. Stockman LJ, Bellamy R, Garner P. SARS: systematic review of treatment effects. PLoS Med. 2006;3:e343. - PMC - PubMed
1. Arabi YM, Mandourah Y, Al-Hameed F. Corticosteroid therapy for critically ill patients with middle east respiratory syndrome. Am J Respir Crit Care Med. 2018;197:757–767. - PubMed
1. Huang C, Wang Y, Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 doi: 10.1016/S0140-6736(20)30183-5. published online Jan 24. - DOI - PMC - PubMed
1. WHO . World Health Organization; Geneva: Jan 28, 2020. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.https://www.who.int/publications-detail/clinical-management-of-severe-ac...
1. Lee N, Allen Chan KC, Hui DS. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol. 2004;31:304–309. - PMC - PubMed

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[1] Stockman LJ, Bellamy R, Garner P. SARS: systematic review of treatment effects. PLoS Med. 2006;3:e343. - PMC - PubMed

[2] Stockman LJ, Bellamy R, Garner P. SARS: systematic review of treatment effects. PLoS Med. 2006;3:e343. - PMC - PubMed

[3] Arabi YM, Mandourah Y, Al-Hameed F. Corticosteroid therapy for critically ill patients with middle east respiratory syndrome. Am J Respir Crit Care Med. 2018;197:757–767. - PubMed

[4] Arabi YM, Mandourah Y, Al-Hameed F. Corticosteroid therapy for critically ill patients with middle east respiratory syndrome. Am J Respir Crit Care Med. 2018;197:757–767. - PubMed

[5] Huang C, Wang Y, Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 doi: 10.1016/S0140-6736(20)30183-5. published online Jan 24. - DOI - PMC - PubMed

[6] Huang C, Wang Y, Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 doi: 10.1016/S0140-6736(20)30183-5. published online Jan 24. - DOI - PMC - PubMed

[7] WHO . World Health Organization; Geneva: Jan 28, 2020. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.https://www.who.int/publications-detail/clinical-management-of-severe-ac...

[8] WHO . World Health Organization; Geneva: Jan 28, 2020. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected.https://www.who.int/publications-detail/clinical-management-of-severe-ac...

[9] Lee N, Allen Chan KC, Hui DS. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol. 2004;31:304–309. - PMC - PubMed

[10] Lee N, Allen Chan KC, Hui DS. Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients. J Clin Virol. 2004;31:304–309. - PMC - PubMed

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Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

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Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury

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