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Review
. 2020 Apr 15;389(2):111899.
doi: 10.1016/j.yexcr.2020.111899. Epub 2020 Feb 8.

Centromere chromatin structure - Lessons from neocentromeres

Catherine Naughton  1 , Nick Gilbert  2
Affiliations
Review

Centromere chromatin structure - Lessons from neocentromeres

Catherine Naughton et al. Exp Cell Res. .

Abstract

Centromeres are highly specialized genomic loci that function during mitosis to maintain genome stability. Formed primarily on repetitive α-satellite DNA sequence characterisation of native centromeric chromatin structure has remained challenging. Fortuitously, neocentromeres are formed on a unique DNA sequence and represent an excellent model to interrogate centromeric chromatin structure. This review uncovers the specific findings from independent neocentromere studies that have advanced our understanding of canonical centromere chromatin structure.

Keywords: Centromere; Chromatin; Neocentromere; α-satellite.

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Conflict of interest statement

Declaration of competing interest None.

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