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. 2020 May 4;26(25):5607-5610.
doi: 10.1002/chem.202000411. Epub 2020 Apr 17.

Cobalt(II)-Catalyzed [4+2] Annulation of Picolinamides with Alkynes via C-H Bond Activation

Yongqi Yao  1 , Qifu Lin  1 , Wen Yang  1 , Weitao Yang  1 , Fenglong Gu  1 , Wei Guo  2 , Dingqiao Yang  1
Affiliations

Cobalt(II)-Catalyzed [4+2] Annulation of Picolinamides with Alkynes via C-H Bond Activation

Yongqi Yao et al. Chemistry. .

Abstract

A cobalt(II)-catalyzed [4+2] annulation of picolinamides with alkynes via C-H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl-substituted 1H-benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co-oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.

Keywords: C−H bond activation; [4+2] annulation; alkynes; co-oxidant free; cobalt(II) catalyst.

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