Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Cristin G Welle¹, Yu-Rong Gao², Meijun Ye³, Andrea Lozzi⁴, Adam Boretsky⁵, Erkinay Abliz³, Daniel X Hammer³

Affiliations

¹ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Departments of Neurosurgery and Physiology & Biophysics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Cristin.welle@cuanschutz.edu.
² Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Department of Neuroscience and Multiphoton Imaging Core Facility, University of Rochester Medical Center, Rochester, NY, USA.
³ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA.
⁴ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁵ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Engility Corporation, San Antonio, TX, USA.

PMID: 32045783
DOI: 10.1016/j.biomaterials.2020.119831

Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Cristin G Welle et al. Biomaterials. 2020 Apr.

. 2020 Apr:238:119831.

doi: 10.1016/j.biomaterials.2020.119831. Epub 2020 Jan 31.

Authors

Cristin G Welle¹, Yu-Rong Gao², Meijun Ye³, Andrea Lozzi⁴, Adam Boretsky⁵, Erkinay Abliz³, Daniel X Hammer³

Affiliations

¹ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Departments of Neurosurgery and Physiology & Biophysics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. Electronic address: Cristin.welle@cuanschutz.edu.
² Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Department of Neuroscience and Multiphoton Imaging Core Facility, University of Rochester Medical Center, Rochester, NY, USA.
³ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA.
⁴ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
⁵ Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Radiological Devices, Food and Drug Administration, Silver Spring, MD, USA; Engility Corporation, San Antonio, TX, USA.

PMID: 32045783
DOI: 10.1016/j.biomaterials.2020.119831

Abstract

Implanted microelectrode arrays sense local neuronal activity, signals which are used as control commands for brain computer interface (BCI) technology. Patients with tetraplegia have used BCI technology to achieve an extraordinary degree of interaction with their local environment. However, current microelectrode arrays for BCIs lose the ability to record high-quality neural signals in the months-to-years following implantation. Very little is known regarding the dynamic response of neurons and vasculature in the months following electrode array implantation, but loss of structural integrity near the electrode may contribute to the degradation of recording signals. Here, we use in-vivo dual-modality imaging to characterize neuronal and vasculature structures in the same animal for 3 months following electrode insertion. We find ongoing neuronal atrophy, but relative vascular stability, in close proximity to the electrode, along with evidence suggesting links between rare, abrupt hypoxic events and neuronal process atrophy.

Keywords: Chronic. (Min.5-Max. 8); Dendrite; Microelectrode; Neuroprosthetic; Vascular.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Affiliations

Longitudinal neural and vascular structural dynamics produced by chronic microelectrode implantation

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources