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. 2020 Feb 11;20(1):49.
doi: 10.1186/s12903-020-1038-4.

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Qiong Wu  1   2 , May Lei Mei  3 , Xin Wu  4 , Shuya Shi  5 , Yuting Xu  6 , Chun Hung Chu  7 , Yaming Chen  8   9
Affiliations

Remineralising effect of 45S5 bioactive glass on artificial caries in dentine

Qiong Wu et al. BMC Oral Health. .

Abstract

Background: This study investigated the remineralisation effect of bioactive glass on artificial dentine caries.

Methods: Dentine disks with artificial caries were treated with bioactive glass (group BAG), casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (group CPP-ACP), sodium fluoride glycerol (group F) or deionized water (group W). All disks were subjected to pH cycling for 28 days subsequently. The topography, microhardness and remineralisation depth of the dentine carious lesion were assessed by atomic force microscopy (AFM), microhardness testing and confocal laser scanning microscope (CLSM), respectively.

Results: AFM images indicated mineral depositions on the surface of the carious lesion in group BAG. The changes of Vickers hardness number (ΔVHN, mean ± SD) after pH cycling were 9.67 ± 3.60, 6.06 ± 3.83, 5.00 ± 2.19 and - 1.90 ± 2.09 (p < 0.001) in group BAG, group CPP-ACP, group F and group W, respectively. The remineralisation depth (mean ± SD) of the carious lesion in group BAG, group CPP-ACP, group F and group W were 165 ± 11 μm, 111 ± 11 μm, 75 ± 6 μm and 0 μm (p < 0.001), respectively.

Conclusion: Bioactive glass possessed a promising remineralisation effect on artificial dentine caries and could be a therapeutic choice for caries management.

Keywords: Artificial caries; Bioactive glass; CPP-ACP; Dentine; Remineralisation.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flowchart of experimental design
Fig. 2
Fig. 2
AFM micrographs in the tapping mode of specimen surfaces after 28-day treatment by bioactive glass a, sodium fluoride glycerin b, CPP-ACP c and deionized water d
Fig. 3
Fig. 3
Confocal Laser Scanning Microscopy representative image of artificial dentin caries treated by bioactive glass (4–1), sodium fluoride glycerin (4–2), CPP-ACP (4–3) and deionized water (4–4). (L, lesion; D, sound dentin; P, precipitation band)
See this image and copyright information in PMC

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