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. 2020 Feb-Mar;81(2-3):101-104.
doi: 10.1016/j.humimm.2020.01.009. Epub 2020 Feb 9.

Siglec-10 expression is up-regulated in activated human CD4+ T cells

E Bandala-Sanchez  1 , N G Bediaga  1 , G Naselli  1 , A M Neale  1 , L C Harrison  2
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Siglec-10 expression is up-regulated in activated human CD4+ T cells

E Bandala-Sanchez et al. Hum Immunol. 2020 Feb-Mar.

Abstract

Most sialic acid-binding immunoglobulin-like lectins (Siglecs) suppress immune cell function but are expressed at low levels on human T cells. We found that soluble CD52 inhibited T cell signalling by ligating Siglec-10, but the presence of Siglec-10 on human T cells has been questioned. To address this concern, we examined the expression of Siglec-10 at the RNA and protein level in human CD4+ T cells. Analysis by RNAseq, qPCR and flow cytometry demonstrated that, in contrast to other Siglecs, after activation of CD4+ T cells Siglec-10 was selectively upregulated in a subset of cells also high for CD52 expression. This observation is consistent with a homeostatic role for Siglec-10 in human CD4+ T cells.

Keywords: Activation; CD4(+) T cell; CD52; Protein; RNA; Siglec-10.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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