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. 2020 Apr 1;30(7):127005.
doi: 10.1016/j.bmcl.2020.127005. Epub 2020 Feb 3.

Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species

Sangkeun Son  1 , Mina Jang  2 , Byeongsan Lee  1 , Jung-Sook Lee  3 , Young-Soo Hong  2 , Bo Yeon Kim  2 , Sung-Kyun Ko  4 , Jae-Hyuk Jang  5 , Jong Seog Ahn  6
Affiliations

Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species

Sangkeun Son et al. Bioorg Med Chem Lett. .

Abstract

Two new macrolide metabolites of the hygrolidin family, catenulisporidins A and B (1 and 2), together with a known compound hygrolidin (3), were isolated from the culture broth of the rare actinobacterium Catenulispora sp. KCB13F192. Their structures were elucidated on the basis of HRESIMS spectrometric and NMR spectroscopic analyses. Catenulisporidins A and B are the first example of natural hygrolidin and bafilomycin derivatives featuring a modified macrolide ring, and catenulisporidin A possesses a tetrahydrofuran ring through an ether linkage between C-7 and C-10. In cell-based fluorescent imaging and immunoblot assays, the three compounds were shown to inhibit autophagic flux in HeLa cells.

Keywords: Actinomycetes; Autophagy; Hygrolidins; Secondary metabolites.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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