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Review
. 2020 Jan 28:10:3129.
doi: 10.3389/fimmu.2019.03129. eCollection 2019.

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang  1   2 , Shushan Yan  3 , Jinghan Yang  1   2 , Hongying Lu  4 , Donghua Xu  1   2 , Zengyan Wang  5
Affiliations
Review

Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang et al. Front Immunol. .

Abstract

Rheumatoid arthritis is a common systemic and autoimmune disease characterized by symmetrical and inflammatory destruction of distal joints. Its primary pathological characters are synovitis and vasculitis. Accumulating studies have implicated the critical role of non-coding RNAs (ncRNAs) in inflammation and autoimmune regulation, primarily including microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA). NcRNAs are significant regulators in distinct physiological and pathophysiological processes. Many validated non-coding RNAs have been identified as promising biomarkers for the diagnosis and treatment of RA. This review will shed some light on RA pathogenesis and be helpful for identifying potential ncRNA biomarkers for RA.

Keywords: circRNA; exosome; lncRNA; microRNA; non-coding RNA; rheumatoid arthritis.

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Figures

Figure 1
Figure 1
Signaling pathway of ncRNAs in RA. NcRNAs (miRNA, lncRNA, circRNA) are involved in regulating inflammation and autoimmunity, such as immune cell activation, differentiation, and polarization. Some ncRNAs are encapsulated in nanovesicles and exert critical effects on inflammatory and immune cells, and some can function as ceRNA by sponging miRNAs in RA. NcRNAs participate in RA inflammation and autoimmune disorders primarily through TLR4/NF-κB, MAPK/PI3K, and Wnt3a/β-catenin signaling pathways, and so on.
Figure 2
Figure 2
Functional role of ncRNAs as ceRNA. A number of miRNAs, lncRNAs, circRNAs, pseudogenes, and competing mRNAs can act as ceRNA and promote the expression of targeted mRNAs via sponging miRNAs. CeRNA network is a crucial mechanism of ncRNAs involved in RA pathogenesis.
See this image and copyright information in PMC

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